American Airlines flights from New York LaGuardia (LGA) to Des Moines (DSM).

Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Fri 16:29 New York LaGuardia (LGA) B 18:41 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 175 (E75) 3:12 Valid until 2025-05-02
Mon-Thu,Sat,Sun 16:50 New York LaGuardia (LGA) B 19:01 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 175 (E75) 3:11 Valid until 2025-05-04
Mon-Thu,Sun 17:00 New York LaGuardia (LGA) B 18:59 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:59 Effective 2025-05-05 through 2025-05-22
Fri 17:00 New York LaGuardia (LGA) B 18:59 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 175 (E75) 2:59 Effective 2025-05-09 through 2025-05-16
Mon-Fri,Sun 17:00 New York LaGuardia (LGA) B 18:59 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:59 Effective 2025-05-23 through 2025-06-04
Daily 17:00 New York LaGuardia (LGA) B 19:14 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 175 (E75) 3:14 Effective 2025-11-02 through 2025-12-02
Daily 17:00 New York LaGuardia (LGA) B 19:12 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 170 / EMB 175 (E70) 3:12 Effective 2025-12-18 through 2026-01-05
Daily 17:00 New York LaGuardia (LGA) B 19:18 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 175 (E75) 3:18 Effective 2026-01-06 through 2026-02-11
Daily 17:00 New York LaGuardia (LGA) B 19:21 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 170 / EMB 175 (E70) 3:21 Effective from 2026-02-12
Mon-Fri,Sun 17:15 New York LaGuardia (LGA) B 19:18 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 175 (E75) 3:03 Effective 2025-06-05 through 2025-07-04
Mon-Fri,Sun 17:15 New York LaGuardia (LGA) B 19:23 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 175 (E75) 3:08 Effective 2025-07-06 through 2025-08-05
Daily 17:30 New York LaGuardia (LGA) B 19:31 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 175 (E75) 3:01 Effective 2025-09-03 through 2025-10-05
Daily 17:45 New York LaGuardia (LGA) B 19:49 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 175 (E75) 3:04 Effective 2025-12-03 through 2025-12-17
Daily 18:00 New York LaGuardia (LGA) B 20:02 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 175 (E75) 3:02 Effective 2025-08-06 through 2025-09-02
Daily 18:00 New York LaGuardia (LGA) B 20:11 Des Moines (DSM)
American Airlines AA 4395 Non-stop Embraer EMB 175 (E75) 3:11 Effective 2025-10-06 through 2025-11-01
Wed 22:00 New York LaGuardia (LGA) B 23:58 Des Moines (DSM)
American Airlines AA 4473 Non-stop Embraer EMB 175 (E75) 2:58 Operates only on 2025-06-04




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American Airlines flights from New York LaGuardia (LGA) to Des Moines (DSM).
Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4395
16:29
New York LaGuardia (LGA) B

18:41
Des Moines (DSM)
Valid until 2025-05-02
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Duration: 3:12, non-stop
Embraer EMB 175 (E75)
American Airlines AA4395
16:50
New York LaGuardia (LGA) B

19:01
Des Moines (DSM)
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
-
Sat
Sun
Duration: 3:11, non-stop
Embraer EMB 175 (E75)
American Airlines AA4395
17:00
New York LaGuardia (LGA) B

18:59
Des Moines (DSM)
Effective 2025-05-05 through 2025-05-22
Mon
Tue
Wed
Thu
Fri
-
Sat
-
Sun
Duration: 2:59, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4395
17:00
New York LaGuardia (LGA) B

18:59
Des Moines (DSM)
Effective 2025-05-09 through 2025-05-16
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Duration: 2:59, non-stop
Embraer EMB 175 (E75)
American Airlines AA4395
17:00
New York LaGuardia (LGA) B

18:59
Des Moines (DSM)
Effective 2025-05-23 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:59, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4395
17:00
New York LaGuardia (LGA) B

19:14
Des Moines (DSM)
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:14, non-stop
Embraer EMB 175 (E75)
American Airlines AA4395
17:00
New York LaGuardia (LGA) B

19:12
Des Moines (DSM)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:12, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4395
17:00
New York LaGuardia (LGA) B

19:18
Des Moines (DSM)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:18, non-stop
Embraer EMB 175 (E75)
American Airlines AA4395
17:00
New York LaGuardia (LGA) B

19:21
Des Moines (DSM)
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:21, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4395
17:15
New York LaGuardia (LGA) B

19:18
Des Moines (DSM)
Effective 2025-06-05 through 2025-07-04
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 3:03, non-stop
Embraer EMB 175 (E75)
American Airlines AA4395
17:15
New York LaGuardia (LGA) B

19:23
Des Moines (DSM)
Effective 2025-07-06 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 3:08, non-stop
Embraer EMB 175 (E75)
American Airlines AA4395
17:30
New York LaGuardia (LGA) B

19:31
Des Moines (DSM)
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:01, non-stop
Embraer EMB 175 (E75)
American Airlines AA4395
17:45
New York LaGuardia (LGA) B

19:49
Des Moines (DSM)
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:04, non-stop
Embraer EMB 175 (E75)
American Airlines AA4395
18:00
New York LaGuardia (LGA) B

20:02
Des Moines (DSM)
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:02, non-stop
Embraer EMB 175 (E75)
American Airlines AA4395
18:00
New York LaGuardia (LGA) B

20:11
Des Moines (DSM)
Effective 2025-10-06 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:11, non-stop
Embraer EMB 175 (E75)
American Airlines AA4473
22:00
New York LaGuardia (LGA) B

23:58
Des Moines (DSM)
Operates only on 2025-06-04
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:58, non-stop
Embraer EMB 175 (E75)
  • A domestic route departing from the New York LaGuardia airport (LGA) and arriving at Des Moines airport (DSM).
  • The flight distance is 1027 miles, or 1653 km.
  • The timezone of the departure airport is UTC-5 , and the timezone of the arrival airport is UTC-6 . Current time at the point of departure is (loading...), and (loading...) at the point of arrival. There is a (loading...) hour time difference between the airports.
  • For direct flights, the flight time varies between 2:58 and 3:21.
All LGA-DSM flights
All American Airlines flights
Return (DSM-LGA) flights
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