American Airlines flights from Chicago O'Hare (ORD) to Knoxville (TYS).

FLIGHT SCHEDULE
Direct Flights:
Daily 20:20 Chicago O'Hare (ORD) 3 23:06 Knoxville (TYS) American Airlines AA 3920 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:46 Effective 2026-04-07 through 2026-05-20
Daily 11:40 Chicago O'Hare (ORD) 3 14:20 Knoxville (TYS) American Airlines AA 3934 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:40 Effective from 2026-10-05
Daily 11:40 Chicago O'Hare (ORD) 3 14:29 Knoxville (TYS) American Airlines AA 4431 Non-stop Embraer EMB 175 (E75) 1:49 Effective 2026-09-09 through 2026-10-04
Daily 11:41 Chicago O'Hare (ORD) 3 14:31 Knoxville (TYS) American Airlines AA 4452 Non-stop Embraer EMB 175 (E75) 1:50 Effective 2026-08-05 through 2026-09-08
Daily 20:20 Chicago O'Hare (ORD) 3 23:16 Knoxville (TYS) American Airlines AA 4454 Non-stop Embraer EMB 175 (E75) 1:56 Effective 2026-05-21 through 2026-07-01
Mon,Thu,Fri,Sun 11:41 Chicago O'Hare (ORD) 3 14:31 Knoxville (TYS) American Airlines AA 4495 Non-stop Embraer EMB 175 (E75) 1:50 Valid until 2026-01-05
Daily 11:40 Chicago O'Hare (ORD) 3 14:27 Knoxville (TYS) American Airlines AA 4553 Non-stop Embraer EMB 175 (E75) 1:47 Effective 2026-07-02 through 2026-08-04
Daily 13:11 Chicago O'Hare (ORD) 3 15:56 Knoxville (TYS) American Airlines AA 5027 Non-stop Canadair CRJ 700 (CR7) 1:45 Valid until 2026-01-05
Daily 08:00 Chicago O'Hare (ORD) 3 10:50 Knoxville (TYS) American Airlines AA 5040 Non-stop Canadair CRJ 700 (CR7) 1:50 Valid until 2026-01-05
Sat 19:13 Chicago O'Hare (ORD) 3 21:53 Knoxville (TYS) American Airlines AA 5084 Non-stop Canadair CRJ 700 (CR7) 1:40 Operates only on 2026-01-24
Sat 19:14 Chicago O'Hare (ORD) 3 21:54 Knoxville (TYS) American Airlines AA 5084 Non-stop Canadair CRJ 700 (CR7) 1:40 Effective 2026-01-31 through 2026-02-07
Daily 19:29 Chicago O'Hare (ORD) 3 22:09 Knoxville (TYS) American Airlines AA 5084 Non-stop Canadair CRJ 700 (CR7) 1:40 Effective 2026-01-06 through 2026-01-16
Mon-Fri,Sun 19:29 Chicago O'Hare (ORD) 3 22:09 Knoxville (TYS) American Airlines AA 5084 Non-stop Canadair CRJ 700 (CR7) 1:40 Effective 2026-01-18 through 2026-02-11
Mon,Thu,Fri 13:10 Chicago O'Hare (ORD) 3 15:52 Knoxville (TYS) American Airlines AA 5123 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective 2026-02-12 through 2026-02-20
Mon,Thu,Fri,Sun 13:10 Chicago O'Hare (ORD) 3 15:52 Knoxville (TYS) American Airlines AA 5123 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective 2026-02-22 through 2026-03-06
Tue,Wed 13:16 Chicago O'Hare (ORD) 3 15:58 Knoxville (TYS) American Airlines AA 5123 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective 2026-02-17 through 2026-03-04
Daily 13:10 Chicago O'Hare (ORD) 3 15:55 Knoxville (TYS) American Airlines AA 5168 Non-stop Canadair CRJ 700 (CR7) 1:45 Effective 2026-09-09 through 2026-10-04
Daily 10:07 Chicago O'Hare (ORD) 3 12:46 Knoxville (TYS) American Airlines AA 5181 Non-stop Canadair CRJ 700 (CR7) 1:39 Effective 2026-01-06 through 2026-01-17
Daily 10:07 Chicago O'Hare (ORD) 3 12:46 Knoxville (TYS) American Airlines AA 5181 Non-stop Canadair CRJ 700 (CR7) 1:39 Effective 2026-01-19 through 2026-02-11
Daily 18:30 Chicago O'Hare (ORD) 3 21:15 Knoxville (TYS) American Airlines AA 5195 Non-stop Canadair CRJ 700 (CR7) 1:45 Effective 2026-09-09 through 2026-10-04
Daily 18:30 Chicago O'Hare (ORD) 3 21:04 Knoxville (TYS) American Airlines AA 5196 Non-stop Canadair CRJ 700 (CR7) 1:34 Effective from 2026-10-05
Daily 09:40 Chicago O'Hare (ORD) 3 12:28 Knoxville (TYS) American Airlines AA 5197 Non-stop Canadair CRJ 700 (CR7) 1:48 Effective from 2026-10-05
Daily 09:40 Chicago O'Hare (ORD) 3 12:31 Knoxville (TYS) American Airlines AA 5202 Non-stop Canadair CRJ 700 (CR7) 1:51 Effective 2026-09-09 through 2026-10-04
Daily 18:36 Chicago O'Hare (ORD) 3 21:23 Knoxville (TYS) American Airlines AA 5207 Non-stop Canadair CRJ 700 (CR7) 1:47 Effective 2026-08-05 through 2026-09-08
Daily 09:40 Chicago O'Hare (ORD) 3 12:25 Knoxville (TYS) American Airlines AA 5216 Non-stop Canadair CRJ 700 (CR7) 1:45 Effective 2026-08-05 through 2026-09-08
Sat 14:00 Chicago O'Hare (ORD) 3 16:42 Knoxville (TYS) American Airlines AA 5217 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective 2026-02-14 through 2026-03-07
Mon-Sat 08:00 Chicago O'Hare (ORD) 3 10:43 Knoxville (TYS) American Airlines AA 5222 Non-stop Canadair CRJ 700 (CR7) 1:43 Effective 2026-02-12 through 2026-03-07
Sun 08:00 Chicago O'Hare (ORD) 3 10:43 Knoxville (TYS) American Airlines AA 5222 Non-stop Canadair CRJ 700 (CR7) 1:43 Effective 2026-02-22 through 2026-03-01
Mon,Wed-Sun 08:00 Chicago O'Hare (ORD) 3 10:45 Knoxville (TYS) American Airlines AA 5222 Non-stop Canadair CRJ 700 (CR7) 1:45 Effective 2026-03-08 through 2026-04-06
Tue 08:05 Chicago O'Hare (ORD) 3 10:50 Knoxville (TYS) American Airlines AA 5222 Non-stop Canadair CRJ 700 (CR7) 1:45 Effective 2026-03-10 through 2026-03-31
Sun 13:10 Chicago O'Hare (ORD) 3 15:52 Knoxville (TYS) American Airlines AA 5222 Non-stop Canadair CRJ 700 (CR7) 1:42 Operates only on 2026-02-15
Daily 13:55 Chicago O'Hare (ORD) 3 16:35 Knoxville (TYS) American Airlines AA 5225 Non-stop Canadair CRJ 700 (CR7) 1:40 Effective 2026-08-05 through 2026-09-08
Mon-Fri,Sun 13:49 Chicago O'Hare (ORD) 3 16:31 Knoxville (TYS) American Airlines AA 5232 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective 2026-03-08 through 2026-04-06
Sat 14:57 Chicago O'Hare (ORD) 3 17:39 Knoxville (TYS) American Airlines AA 5232 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective 2026-03-14 through 2026-04-04
Daily 18:33 Chicago O'Hare (ORD) 3 21:21 Knoxville (TYS) American Airlines AA 5333 Non-stop Canadair CRJ 700 (CR7) 1:48 Valid until 2026-01-05
Daily 13:10 Chicago O'Hare (ORD) 3 15:52 Knoxville (TYS) American Airlines AA 5338 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective from 2026-10-05
Daily 18:30 Chicago O'Hare (ORD) 3 21:12 Knoxville (TYS) American Airlines AA 5341 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective 2026-05-21 through 2026-07-01
Daily 18:30 Chicago O'Hare (ORD) 3 21:17 Knoxville (TYS) American Airlines AA 5341 Non-stop Canadair CRJ 700 (CR7) 1:47 Effective 2026-07-02 through 2026-08-04
Daily 13:10 Chicago O'Hare (ORD) 3 15:44 Knoxville (TYS) American Airlines AA 5378 Non-stop Canadair CRJ 700 (CR7) 1:34 Effective 2026-05-21 through 2026-07-01
Daily 13:10 Chicago O'Hare (ORD) 3 15:49 Knoxville (TYS) American Airlines AA 5378 Non-stop Canadair CRJ 700 (CR7) 1:39 Effective 2026-07-02 through 2026-08-04
Daily 09:40 Chicago O'Hare (ORD) 3 12:19 Knoxville (TYS) American Airlines AA 5420 Non-stop Canadair CRJ 700 (CR7) 1:39 Effective 2026-07-02 through 2026-08-04
Daily 09:40 Chicago O'Hare (ORD) 3 12:21 Knoxville (TYS) American Airlines AA 5434 Non-stop Canadair CRJ 700 (CR7) 1:41 Effective 2026-05-21 through 2026-07-01
Sun 18:03 Chicago O'Hare (ORD) 3 20:46 Knoxville (TYS) American Airlines AA 5454 Non-stop Canadair CRJ 700 (CR7) 1:43 Operates only on 2026-02-15
Mon,Thu,Fri 18:40 Chicago O'Hare (ORD) 3 21:23 Knoxville (TYS) American Airlines AA 5454 Non-stop Canadair CRJ 700 (CR7) 1:43 Effective 2026-02-12 through 2026-02-20
Mon,Thu,Fri,Sun 18:40 Chicago O'Hare (ORD) 3 21:23 Knoxville (TYS) American Airlines AA 5454 Non-stop Canadair CRJ 700 (CR7) 1:43 Effective 2026-02-22 through 2026-03-06
Tue,Wed 18:45 Chicago O'Hare (ORD) 3 21:28 Knoxville (TYS) American Airlines AA 5454 Non-stop Canadair CRJ 700 (CR7) 1:43 Effective 2026-02-17 through 2026-03-04
Mon-Fri,Sun 18:48 Chicago O'Hare (ORD) 3 21:32 Knoxville (TYS) American Airlines AA 5454 Non-stop Canadair CRJ 700 (CR7) 1:44 Effective 2026-03-08 through 2026-04-06
Daily 11:40 Chicago O'Hare (ORD) 3 14:27 Knoxville (TYS) American Airlines AA 5467 Non-stop Canadair CRJ 700 (CR7) 1:47 Effective 2026-04-07 through 2026-05-20
Daily 08:00 Chicago O'Hare (ORD) 3 10:46 Knoxville (TYS) American Airlines AA 5468 Non-stop Canadair CRJ 700 (CR7) 1:46 Effective 2026-04-07 through 2026-05-20
Daily 16:40 Chicago O'Hare (ORD) 3 19:26 Knoxville (TYS) American Airlines AA 5469 Non-stop Canadair CRJ 700 (CR7) 1:46 Effective 2026-04-07 through 2026-05-20

A domestic route departing from the Chicago O'Hare airport (ORD) and arriving at Knoxville airport (TYS).
The flight distance is 475 miles, or 764 km.
The timezone of the departure airport is UTC-6 , and the timezone of the arrival airport is UTC-5 . Current time at the point of departure is (loading...), and (loading...) at the point of arrival. There is a (loading...) hour time difference between the airports.
For direct flights, the flight time varies between 1:34 and 1:56.

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FLIGHT SCHEDULE

Direct Flights:

American Airlines AA3920

20:20

Chicago O'Hare (ORD) 3

23:06

Knoxville (TYS)

Effective 2026-04-07 through 2026-05-20

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:46, non-stop
Embraer EMB 170 / EMB 175 (E70)

Direct Flights:

American Airlines AA3934

11:40

Chicago O'Hare (ORD) 3

14:20

Knoxville (TYS)

Effective from 2026-10-05

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:40, non-stop
Embraer EMB 170 / EMB 175 (E70)

Direct Flights:

American Airlines AA4431

11:40

Chicago O'Hare (ORD) 3

14:29

Knoxville (TYS)

Effective 2026-09-09 through 2026-10-04

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:49, non-stop
Embraer EMB 175 (E75)

Direct Flights:

American Airlines AA4452

11:41

Chicago O'Hare (ORD) 3

14:31

Knoxville (TYS)

Effective 2026-08-05 through 2026-09-08

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:50, non-stop
Embraer EMB 175 (E75)

Direct Flights:

American Airlines AA4454

20:20

Chicago O'Hare (ORD) 3

23:16

Knoxville (TYS)

Effective 2026-05-21 through 2026-07-01

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:56, non-stop
Embraer EMB 175 (E75)

Direct Flights:

American Airlines AA4495

11:41

Chicago O'Hare (ORD) 3

14:31

Knoxville (TYS)

Valid until 2026-01-05

Mon

Tue
-

Wed
-

Thu

Fri

Sat
-

Sun

Duration: 1:50, non-stop
Embraer EMB 175 (E75)

Direct Flights:

American Airlines AA4553

11:40

Chicago O'Hare (ORD) 3

14:27

Knoxville (TYS)

Effective 2026-07-02 through 2026-08-04

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:47, non-stop
Embraer EMB 175 (E75)

Direct Flights:

American Airlines AA5027

13:11

Chicago O'Hare (ORD) 3

15:56

Knoxville (TYS)

Valid until 2026-01-05

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:45, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5040

08:00

Chicago O'Hare (ORD) 3

10:50

Knoxville (TYS)

Valid until 2026-01-05

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:50, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5084

19:13

Chicago O'Hare (ORD) 3

21:53

Knoxville (TYS)

Operates only on 2026-01-24

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat

Sun
-

Duration: 1:40, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5084

19:14

Chicago O'Hare (ORD) 3

21:54

Knoxville (TYS)

Effective 2026-01-31 through 2026-02-07

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat

Sun
-

Duration: 1:40, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5084

19:29

Chicago O'Hare (ORD) 3

22:09

Knoxville (TYS)

Effective 2026-01-06 through 2026-01-16

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:40, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5084

19:29

Chicago O'Hare (ORD) 3

22:09

Knoxville (TYS)

Effective 2026-01-18 through 2026-02-11

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 1:40, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5123

13:10

Chicago O'Hare (ORD) 3

15:52

Knoxville (TYS)

Effective 2026-02-12 through 2026-02-20

Mon

Tue
-

Wed
-

Thu

Fri

Sat
-

Sun
-

Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5123

13:10

Chicago O'Hare (ORD) 3

15:52

Knoxville (TYS)

Effective 2026-02-22 through 2026-03-06

Mon

Tue
-

Wed
-

Thu

Fri

Sat
-

Sun

Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5123

13:16

Chicago O'Hare (ORD) 3

15:58

Knoxville (TYS)

Effective 2026-02-17 through 2026-03-04

Mon
-

Tue

Wed

Thu
-

Fri
-

Sat
-

Sun
-

Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5168

13:10

Chicago O'Hare (ORD) 3

15:55

Knoxville (TYS)

Effective 2026-09-09 through 2026-10-04

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:45, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5181

10:07

Chicago O'Hare (ORD) 3

12:46

Knoxville (TYS)

Effective 2026-01-06 through 2026-01-17

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:39, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5181

10:07

Chicago O'Hare (ORD) 3

12:46

Knoxville (TYS)

Effective 2026-01-19 through 2026-02-11

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:39, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5195

18:30

Chicago O'Hare (ORD) 3

21:15

Knoxville (TYS)

Effective 2026-09-09 through 2026-10-04

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:45, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5196

18:30

Chicago O'Hare (ORD) 3

21:04

Knoxville (TYS)

Effective from 2026-10-05

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:34, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5197

09:40

Chicago O'Hare (ORD) 3

12:28

Knoxville (TYS)

Effective from 2026-10-05

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:48, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5202

09:40

Chicago O'Hare (ORD) 3

12:31

Knoxville (TYS)

Effective 2026-09-09 through 2026-10-04

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:51, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5207

18:36

Chicago O'Hare (ORD) 3

21:23

Knoxville (TYS)

Effective 2026-08-05 through 2026-09-08

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:47, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5216

09:40

Chicago O'Hare (ORD) 3

12:25

Knoxville (TYS)

Effective 2026-08-05 through 2026-09-08

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:45, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5217

14:00

Chicago O'Hare (ORD) 3

16:42

Knoxville (TYS)

Effective 2026-02-14 through 2026-03-07

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat

Sun
-

Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5222

08:00

Chicago O'Hare (ORD) 3

10:43

Knoxville (TYS)

Effective 2026-02-12 through 2026-03-07

Mon

Tue

Wed

Thu

Fri

Sat

Sun
-

Duration: 1:43, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5222

08:00

Chicago O'Hare (ORD) 3

10:43

Knoxville (TYS)

Effective 2026-02-22 through 2026-03-01

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat
-

Sun

Duration: 1:43, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5222

08:00

Chicago O'Hare (ORD) 3

10:45

Knoxville (TYS)

Effective 2026-03-08 through 2026-04-06

Mon

Tue
-

Wed

Thu

Fri

Sat

Sun

Duration: 1:45, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5222

08:05

Chicago O'Hare (ORD) 3

10:50

Knoxville (TYS)

Effective 2026-03-10 through 2026-03-31

Mon
-

Tue

Wed
-

Thu
-

Fri
-

Sat
-

Sun
-

Duration: 1:45, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5222

13:10

Chicago O'Hare (ORD) 3

15:52

Knoxville (TYS)

Operates only on 2026-02-15

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat
-

Sun

Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5225

13:55

Chicago O'Hare (ORD) 3

16:35

Knoxville (TYS)

Effective 2026-08-05 through 2026-09-08

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:40, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5232

13:49

Chicago O'Hare (ORD) 3

16:31

Knoxville (TYS)

Effective 2026-03-08 through 2026-04-06

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5232

14:57

Chicago O'Hare (ORD) 3

17:39

Knoxville (TYS)

Effective 2026-03-14 through 2026-04-04

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat

Sun
-

Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5333

18:33

Chicago O'Hare (ORD) 3

21:21

Knoxville (TYS)

Valid until 2026-01-05

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:48, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5338

13:10

Chicago O'Hare (ORD) 3

15:52

Knoxville (TYS)

Effective from 2026-10-05

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5341

18:30

Chicago O'Hare (ORD) 3

21:12

Knoxville (TYS)

Effective 2026-05-21 through 2026-07-01

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5341

18:30

Chicago O'Hare (ORD) 3

21:17

Knoxville (TYS)

Effective 2026-07-02 through 2026-08-04

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:47, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5378

13:10

Chicago O'Hare (ORD) 3

15:44

Knoxville (TYS)

Effective 2026-05-21 through 2026-07-01

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:34, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5378

13:10

Chicago O'Hare (ORD) 3

15:49

Knoxville (TYS)

Effective 2026-07-02 through 2026-08-04

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:39, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5420

09:40

Chicago O'Hare (ORD) 3

12:19

Knoxville (TYS)

Effective 2026-07-02 through 2026-08-04

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:39, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5434

09:40

Chicago O'Hare (ORD) 3

12:21

Knoxville (TYS)

Effective 2026-05-21 through 2026-07-01

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:41, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5454

18:03

Chicago O'Hare (ORD) 3

20:46

Knoxville (TYS)

Operates only on 2026-02-15

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat
-

Sun

Duration: 1:43, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5454

18:40

Chicago O'Hare (ORD) 3

21:23

Knoxville (TYS)

Effective 2026-02-12 through 2026-02-20

Mon

Tue
-

Wed
-

Thu

Fri

Sat
-

Sun
-

Duration: 1:43, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5454

18:40

Chicago O'Hare (ORD) 3

21:23

Knoxville (TYS)

Effective 2026-02-22 through 2026-03-06

Mon

Tue
-

Wed
-

Thu

Fri

Sat
-

Sun

Duration: 1:43, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5454

18:45

Chicago O'Hare (ORD) 3

21:28

Knoxville (TYS)

Effective 2026-02-17 through 2026-03-04

Mon
-

Tue

Wed

Thu
-

Fri
-

Sat
-

Sun
-

Duration: 1:43, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5454

18:48

Chicago O'Hare (ORD) 3

21:32

Knoxville (TYS)

Effective 2026-03-08 through 2026-04-06

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 1:44, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5467

11:40

Chicago O'Hare (ORD) 3

14:27

Knoxville (TYS)

Effective 2026-04-07 through 2026-05-20

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:47, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5468

08:00

Chicago O'Hare (ORD) 3

10:46

Knoxville (TYS)

Effective 2026-04-07 through 2026-05-20

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:46, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5469

16:40

Chicago O'Hare (ORD) 3

19:26

Knoxville (TYS)

Effective 2026-04-07 through 2026-05-20

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:46, non-stop
Canadair CRJ 700 (CR7)

A domestic route departing from the Chicago O'Hare airport (ORD) and arriving at Knoxville airport (TYS).
The flight distance is 475 miles, or 764 km.
The timezone of the departure airport is UTC-6 , and the timezone of the arrival airport is UTC-5 . Current time at the point of departure is (loading...), and (loading...) at the point of arrival. There is a (loading...) hour time difference between the airports.
For direct flights, the flight time varies between 1:34 and 1:56.

All ORD-TYS flights

All American Airlines flights

Return (TYS-ORD) flights

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