Alaska Airlines flights from Chicago O'Hare (ORD) to Knoxville (TYS).

Select flight date:
FLIGHT SCHEDULE
Direct Codeshare Flights:
Daily 18:30 Chicago O'Hare (ORD) 3 21:12 Knoxville (TYS)
Alaska Airlines AS 4481 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective 2026-05-21 through 2026-07-01
Codeshare flight, operated by American Airlines.(AA 5341)
Daily 18:30 Chicago O'Hare (ORD) 3 21:17 Knoxville (TYS)
Alaska Airlines AS 4481 Non-stop Canadair CRJ 700 (CR7) 1:47 Effective 2026-07-02 through 2026-08-04
Codeshare flight, operated by American Airlines.(AA 5341)
Daily 16:40 Chicago O'Hare (ORD) 3 19:26 Knoxville (TYS)
Alaska Airlines AS 4499 Non-stop Canadair CRJ 700 (CR7) 1:46 Effective 2026-04-08 through 2026-05-20
Codeshare flight, operated by American Airlines.(AA 5469)
Daily 13:55 Chicago O'Hare (ORD) 3 16:35 Knoxville (TYS)
Alaska Airlines AS 4533 Non-stop Canadair CRJ 700 (CR7) 1:40 Effective 2026-08-05 through 2026-09-08
Codeshare flight, operated by American Airlines.(AA 5225)
Daily 18:30 Chicago O'Hare (ORD) 3 21:04 Knoxville (TYS)
Alaska Airlines AS 4650 Non-stop Canadair CRJ 700 (CR7) 1:34 Effective from 2026-10-05
Codeshare flight, operated by American Airlines.(AA 5196)
Daily 18:36 Chicago O'Hare (ORD) 3 21:23 Knoxville (TYS)
Alaska Airlines AS 4701 Non-stop Canadair CRJ 700 (CR7) 1:47 Effective 2026-08-05 through 2026-09-08
Codeshare flight, operated by American Airlines.(AA 5207)
Daily 18:30 Chicago O'Hare (ORD) 3 21:15 Knoxville (TYS)
Alaska Airlines AS 4751 Non-stop Canadair CRJ 700 (CR7) 1:45 Effective 2026-09-09 through 2026-10-04
Codeshare flight, operated by American Airlines.(AA 5195)
Wed 09:40 Chicago O'Hare (ORD) 3 12:25 Knoxville (TYS)
Alaska Airlines AS 6203 Non-stop Canadair CRJ 700 (CR7) 1:45 Operates only on 2026-08-05
Codeshare flight, operated by American Airlines.(AA 5216)
Daily 09:40 Chicago O'Hare (ORD) 3 12:21 Knoxville (TYS)
Alaska Airlines AS 6210 Non-stop Canadair CRJ 700 (CR7) 1:41 Effective 2026-05-22 through 2026-07-01
Codeshare flight, operated by American Airlines.(AA 5434)
Daily 09:40 Chicago O'Hare (ORD) 3 12:19 Knoxville (TYS)
Alaska Airlines AS 6210 Non-stop Canadair CRJ 700 (CR7) 1:39 Effective 2026-07-02 through 2026-08-04
Codeshare flight, operated by American Airlines.(AA 5420)
Mon,Thu,Fri,Sun 13:10 Chicago O'Hare (ORD) 3 15:52 Knoxville (TYS)
Alaska Airlines AS 6391 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective 2026-02-12 through 2026-03-06
Codeshare flight, operated by American Airlines.(AA 5123)
Tue,Wed 13:16 Chicago O'Hare (ORD) 3 15:58 Knoxville (TYS)
Alaska Airlines AS 6391 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective 2026-02-17 through 2026-03-04
Codeshare flight, operated by American Airlines.(AA 5123)
Mon-Fri,Sun 13:49 Chicago O'Hare (ORD) 3 16:31 Knoxville (TYS)
Alaska Airlines AS 6391 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective 2026-03-08 through 2026-04-06
Codeshare flight, operated by American Airlines.(AA 5232)
Sat 14:00 Chicago O'Hare (ORD) 3 16:42 Knoxville (TYS)
Alaska Airlines AS 6391 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective 2026-02-14 through 2026-03-07
Codeshare flight, operated by American Airlines.(AA 5217)
Sat 14:57 Chicago O'Hare (ORD) 3 17:39 Knoxville (TYS)
Alaska Airlines AS 6391 Non-stop Canadair CRJ 700 (CR7) 1:42 Effective 2026-03-14 through 2026-04-04
Codeshare flight, operated by American Airlines.(AA 5232)
Mon,Thu,Fri 19:29 Chicago O'Hare (ORD) 3 22:09 Knoxville (TYS)
Alaska Airlines AS 6391 Non-stop Canadair CRJ 700 (CR7) 1:40 Effective 2026-02-05 through 2026-02-09
Codeshare flight, operated by American Airlines.(AA 5084)
Daily 13:10 Chicago O'Hare (ORD) 3 15:44 Knoxville (TYS)
Alaska Airlines AS 6725 Non-stop Canadair CRJ 700 (CR7) 1:34 Effective 2026-05-21 through 2026-07-01
Codeshare flight, operated by American Airlines.(AA 5378)
Daily 20:20 Chicago O'Hare (ORD) 3 23:06 Knoxville (TYS)
Alaska Airlines AS 6886 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:46 Effective 2026-04-07 through 2026-05-20
Codeshare flight, operated by American Airlines.(AA 3920)
Daily 20:20 Chicago O'Hare (ORD) 3 23:16 Knoxville (TYS)
Alaska Airlines AS 6886 Non-stop Embraer EMB 175 (E75) 1:56 Effective 2026-05-21 through 2026-07-01
Codeshare flight, operated by American Airlines.(AA 4454)




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Alaska Airlines flights from Chicago O'Hare (ORD) to Knoxville (TYS).
Select flight date:
FLIGHT SCHEDULE
Direct Codeshare Flights:
Alaska Airlines AS4481
18:30
Chicago O'Hare (ORD) 3

21:12
Knoxville (TYS)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5341)
Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS4481
18:30
Chicago O'Hare (ORD) 3

21:17
Knoxville (TYS)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5341)
Duration: 1:47, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS4499
16:40
Chicago O'Hare (ORD) 3

19:26
Knoxville (TYS)
Effective 2026-04-08 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5469)
Duration: 1:46, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS4533
13:55
Chicago O'Hare (ORD) 3

16:35
Knoxville (TYS)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5225)
Duration: 1:40, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS4650
18:30
Chicago O'Hare (ORD) 3

21:04
Knoxville (TYS)
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5196)
Duration: 1:34, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS4701
18:36
Chicago O'Hare (ORD) 3

21:23
Knoxville (TYS)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5207)
Duration: 1:47, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS4751
18:30
Chicago O'Hare (ORD) 3

21:15
Knoxville (TYS)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5195)
Duration: 1:45, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS6203
09:40
Chicago O'Hare (ORD) 3

12:25
Knoxville (TYS)
Operates only on 2026-08-05
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 5216)
Duration: 1:45, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS6210
09:40
Chicago O'Hare (ORD) 3

12:21
Knoxville (TYS)
Effective 2026-05-22 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5434)
Duration: 1:41, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS6210
09:40
Chicago O'Hare (ORD) 3

12:19
Knoxville (TYS)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5420)
Duration: 1:39, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS6391
13:10
Chicago O'Hare (ORD) 3

15:52
Knoxville (TYS)
Effective 2026-02-12 through 2026-03-06
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 5123)
Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS6391
13:16
Chicago O'Hare (ORD) 3

15:58
Knoxville (TYS)
Effective 2026-02-17 through 2026-03-04
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 5123)
Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS6391
13:49
Chicago O'Hare (ORD) 3

16:31
Knoxville (TYS)
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 5232)
Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS6391
14:00
Chicago O'Hare (ORD) 3

16:42
Knoxville (TYS)
Effective 2026-02-14 through 2026-03-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 5217)
Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS6391
14:57
Chicago O'Hare (ORD) 3

17:39
Knoxville (TYS)
Effective 2026-03-14 through 2026-04-04
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 5232)
Duration: 1:42, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS6391
19:29
Chicago O'Hare (ORD) 3

22:09
Knoxville (TYS)
Effective 2026-02-05 through 2026-02-09
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 5084)
Duration: 1:40, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS6725
13:10
Chicago O'Hare (ORD) 3

15:44
Knoxville (TYS)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5378)
Duration: 1:34, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS6886
20:20
Chicago O'Hare (ORD) 3

23:06
Knoxville (TYS)
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 3920)
Duration: 1:46, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Codeshare Flights:
Alaska Airlines AS6886
20:20
Chicago O'Hare (ORD) 3

23:16
Knoxville (TYS)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 4454)
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
  • A domestic route departing from the Chicago O'Hare airport (ORD) and arriving at Knoxville airport (TYS).
  • The flight distance is 475 miles, or 764 km.
  • The timezone of the departure airport is UTC-6 , and the timezone of the arrival airport is UTC-5 . Current time at the point of departure is (loading...), and (loading...) at the point of arrival. There is a (loading...) hour time difference between the airports.
  • For direct flights, the flight time varies between 1:34 and 1:56.
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