American Airlines flights from Philadelphia (PHL) to Knoxville (TYS).

Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 18:34 Philadelphia (PHL) F 20:43 Knoxville (TYS)
American Airlines AA 5066 Non-stop Canadair CRJ 900 (CR9) 2:09 Valid until 2026-01-05
Daily 18:35 Philadelphia (PHL) F 20:39 Knoxville (TYS)
American Airlines AA 5066 Non-stop Canadair CRJ 900 (CR9) 2:04 Effective 2026-04-07 through 2026-05-20
Daily 18:35 Philadelphia (PHL) F 20:38 Knoxville (TYS)
American Airlines AA 5066 Non-stop Canadair CRJ 900 (CR9) 2:03 Effective 2026-05-21 through 2026-07-01
Daily 18:35 Philadelphia (PHL) F 20:36 Knoxville (TYS)
American Airlines AA 5066 Non-stop Canadair CRJ 900 (CR9) 2:01 Effective 2026-07-02 through 2026-08-04
Daily 18:44 Philadelphia (PHL) F 20:56 Knoxville (TYS)
American Airlines AA 5066 Non-stop Canadair CRJ 900 (CR9) 2:12 Effective 2026-01-06 through 2026-02-11
Daily 18:35 Philadelphia (PHL) F 20:48 Knoxville (TYS)
American Airlines AA 5352 Non-stop Canadair CRJ 900 (CR9) 2:13 Effective 2026-09-09 through 2026-10-04
Daily 18:35 Philadelphia (PHL) F 20:35 Knoxville (TYS)
American Airlines AA 5352 Non-stop Canadair CRJ 900 (CR9) 2:00 Effective from 2026-10-05
Daily 18:40 Philadelphia (PHL) F 20:49 Knoxville (TYS)
American Airlines AA 5352 Non-stop Canadair CRJ 900 (CR9) 2:09 Effective 2026-08-05 through 2026-09-08
Daily 15:35 Philadelphia (PHL) F 17:36 Knoxville (TYS)
American Airlines AA 5866 Non-stop Embraer ERJ 145 (ER4) 2:01 Effective from 2026-10-05
Daily 15:35 Philadelphia (PHL) F 17:35 Knoxville (TYS)
American Airlines AA 5879 Non-stop Embraer ERJ 145 (ER4) 2:00 Effective 2026-04-07 through 2026-05-20
Daily 08:20 Philadelphia (PHL) F 10:32 Knoxville (TYS)
American Airlines AA 5883 Non-stop Embraer ERJ 145 (ER4) 2:12 Effective 2026-04-07 through 2026-05-20
Daily 08:10 Philadelphia (PHL) F 10:14 Knoxville (TYS)
American Airlines AA 5950 Non-stop Embraer ERJ 145 (ER4) 2:04 Effective 2026-07-02 through 2026-08-04
Daily 08:10 Philadelphia (PHL) F 10:12 Knoxville (TYS)
American Airlines AA 5951 Non-stop Embraer ERJ 145 (ER4) 2:02 Effective 2026-05-21 through 2026-07-01
Daily 15:35 Philadelphia (PHL) F 17:33 Knoxville (TYS)
American Airlines AA 5952 Non-stop Embraer ERJ 145 (ER4) 1:58 Effective 2026-05-21 through 2026-07-01
Daily 15:35 Philadelphia (PHL) F 17:35 Knoxville (TYS)
American Airlines AA 5952 Non-stop Embraer ERJ 145 (ER4) 2:00 Effective 2026-07-02 through 2026-08-04
Daily 08:10 Philadelphia (PHL) F 10:19 Knoxville (TYS)
American Airlines AA 5956 Non-stop Embraer ERJ 145 (ER4) 2:09 Effective from 2026-10-05
Mon,Thu-Sun 08:10 Philadelphia (PHL) F 10:24 Knoxville (TYS)
American Airlines AA 5961 Non-stop Embraer ERJ 145 (ER4) 2:14 Valid until 2026-01-05
Daily 12:18 Philadelphia (PHL) F 14:32 Knoxville (TYS)
American Airlines AA 5961 Non-stop Embraer ERJ 145 (ER4) 2:14 Effective 2026-01-06 through 2026-02-11
Tue 18:45 Philadelphia (PHL) F 20:57 Knoxville (TYS)
American Airlines AA 5961 Non-stop Embraer ERJ 145 (ER4) 2:12 Effective 2026-03-10 through 2026-03-31
Mon,Wed-Sun 18:53 Philadelphia (PHL) F 21:05 Knoxville (TYS)
American Airlines AA 5961 Non-stop Embraer ERJ 145 (ER4) 2:12 Effective 2026-03-08 through 2026-04-06
Daily 10:25 Philadelphia (PHL) F 12:30 Knoxville (TYS)
American Airlines AA 5968 Non-stop Embraer ERJ 145 (ER4) 2:05 Effective from 2026-10-05
Mon,Thu-Sun 13:36 Philadelphia (PHL) F 15:47 Knoxville (TYS)
American Airlines AA 6014 Non-stop Embraer ERJ 145 (ER4) 2:11 Valid until 2026-01-05
Daily 08:10 Philadelphia (PHL) F 10:20 Knoxville (TYS)
American Airlines AA 6078 Non-stop Embraer ERJ 145 (ER4) 2:10 Effective 2026-09-09 through 2026-10-04
Daily 10:25 Philadelphia (PHL) F 12:38 Knoxville (TYS)
American Airlines AA 6079 Non-stop Embraer ERJ 145 (ER4) 2:13 Effective 2026-09-09 through 2026-10-04
Daily 15:35 Philadelphia (PHL) F 17:42 Knoxville (TYS)
American Airlines AA 6080 Non-stop Embraer ERJ 145 (ER4) 2:07 Effective 2026-09-09 through 2026-10-04
Daily 08:44 Philadelphia (PHL) F 10:48 Knoxville (TYS)
American Airlines AA 6091 Non-stop Embraer ERJ 145 (ER4) 2:04 Effective 2026-08-05 through 2026-09-08
Daily 15:44 Philadelphia (PHL) F 17:47 Knoxville (TYS)
American Airlines AA 6092 Non-stop Embraer ERJ 145 (ER4) 2:03 Effective 2026-08-05 through 2026-09-08
Mon,Thu,Fri,Sun 13:35 Philadelphia (PHL) F 15:50 Knoxville (TYS)
American Airlines AA 6100 Non-stop Embraer ERJ 145 (ER4) 2:15 Effective 2026-02-12 through 2026-03-06
Mon,Wed-Fri,Sun 13:35 Philadelphia (PHL) F 15:48 Knoxville (TYS)
American Airlines AA 6100 Non-stop Embraer ERJ 145 (ER4) 2:13 Effective 2026-03-08 through 2026-04-06
Sat 13:52 Philadelphia (PHL) F 16:07 Knoxville (TYS)
American Airlines AA 6100 Non-stop Embraer ERJ 145 (ER4) 2:15 Effective 2026-02-14 through 2026-03-07
Sat 14:02 Philadelphia (PHL) F 16:15 Knoxville (TYS)
American Airlines AA 6100 Non-stop Embraer ERJ 145 (ER4) 2:13 Effective 2026-03-14 through 2026-04-04
Tue,Wed 14:08 Philadelphia (PHL) F 16:23 Knoxville (TYS)
American Airlines AA 6100 Non-stop Embraer ERJ 145 (ER4) 2:15 Effective 2026-02-17 through 2026-03-04
Tue 14:08 Philadelphia (PHL) F 16:21 Knoxville (TYS)
American Airlines AA 6100 Non-stop Embraer ERJ 145 (ER4) 2:13 Effective 2026-03-10 through 2026-03-31
Mon,Thu-Sun 19:30 Philadelphia (PHL) F 21:48 Knoxville (TYS)
American Airlines AA 6108 Non-stop Embraer ERJ 145 (ER4) 2:18 Effective 2026-02-12 through 2026-03-07
Tue,Wed 19:44 Philadelphia (PHL) F 22:02 Knoxville (TYS)
American Airlines AA 6108 Non-stop Embraer ERJ 145 (ER4) 2:18 Effective 2026-02-17 through 2026-03-04




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American Airlines flights from Philadelphia (PHL) to Knoxville (TYS).
Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA5066
18:34
Philadelphia (PHL) F

20:43
Knoxville (TYS)
Valid until 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:09, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5066
18:35
Philadelphia (PHL) F

20:39
Knoxville (TYS)
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:04, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5066
18:35
Philadelphia (PHL) F

20:38
Knoxville (TYS)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:03, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5066
18:35
Philadelphia (PHL) F

20:36
Knoxville (TYS)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:01, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5066
18:44
Philadelphia (PHL) F

20:56
Knoxville (TYS)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:12, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5352
18:35
Philadelphia (PHL) F

20:48
Knoxville (TYS)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:13, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5352
18:35
Philadelphia (PHL) F

20:35
Knoxville (TYS)
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:00, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5352
18:40
Philadelphia (PHL) F

20:49
Knoxville (TYS)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:09, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5866
15:35
Philadelphia (PHL) F

17:36
Knoxville (TYS)
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:01, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA5879
15:35
Philadelphia (PHL) F

17:35
Knoxville (TYS)
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:00, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA5883
08:20
Philadelphia (PHL) F

10:32
Knoxville (TYS)
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:12, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA5950
08:10
Philadelphia (PHL) F

10:14
Knoxville (TYS)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:04, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA5951
08:10
Philadelphia (PHL) F

10:12
Knoxville (TYS)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:02, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA5952
15:35
Philadelphia (PHL) F

17:33
Knoxville (TYS)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:58, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA5952
15:35
Philadelphia (PHL) F

17:35
Knoxville (TYS)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:00, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA5956
08:10
Philadelphia (PHL) F

10:19
Knoxville (TYS)
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:09, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA5961
08:10
Philadelphia (PHL) F

10:24
Knoxville (TYS)
Valid until 2026-01-05
Mon
Tue
-
Wed
-
Thu
Fri
Sat
Sun
Duration: 2:14, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA5961
12:18
Philadelphia (PHL) F

14:32
Knoxville (TYS)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:14, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA5961
18:45
Philadelphia (PHL) F

20:57
Knoxville (TYS)
Effective 2026-03-10 through 2026-03-31
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:12, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA5961
18:53
Philadelphia (PHL) F

21:05
Knoxville (TYS)
Effective 2026-03-08 through 2026-04-06
Mon
Tue
-
Wed
Thu
Fri
Sat
Sun
Duration: 2:12, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA5968
10:25
Philadelphia (PHL) F

12:30
Knoxville (TYS)
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:05, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6014
13:36
Philadelphia (PHL) F

15:47
Knoxville (TYS)
Valid until 2026-01-05
Mon
Tue
-
Wed
-
Thu
Fri
Sat
Sun
Duration: 2:11, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6078
08:10
Philadelphia (PHL) F

10:20
Knoxville (TYS)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:10, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6079
10:25
Philadelphia (PHL) F

12:38
Knoxville (TYS)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:13, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6080
15:35
Philadelphia (PHL) F

17:42
Knoxville (TYS)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:07, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6091
08:44
Philadelphia (PHL) F

10:48
Knoxville (TYS)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:04, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6092
15:44
Philadelphia (PHL) F

17:47
Knoxville (TYS)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:03, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6100
13:35
Philadelphia (PHL) F

15:50
Knoxville (TYS)
Effective 2026-02-12 through 2026-03-06
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
Duration: 2:15, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6100
13:35
Philadelphia (PHL) F

15:48
Knoxville (TYS)
Effective 2026-03-08 through 2026-04-06
Mon
Tue
-
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:13, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6100
13:52
Philadelphia (PHL) F

16:07
Knoxville (TYS)
Effective 2026-02-14 through 2026-03-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:15, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6100
14:02
Philadelphia (PHL) F

16:15
Knoxville (TYS)
Effective 2026-03-14 through 2026-04-04
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:13, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6100
14:08
Philadelphia (PHL) F

16:23
Knoxville (TYS)
Effective 2026-02-17 through 2026-03-04
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:15, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6100
14:08
Philadelphia (PHL) F

16:21
Knoxville (TYS)
Effective 2026-03-10 through 2026-03-31
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:13, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6108
19:30
Philadelphia (PHL) F

21:48
Knoxville (TYS)
Effective 2026-02-12 through 2026-03-07
Mon
Tue
-
Wed
-
Thu
Fri
Sat
Sun
Duration: 2:18, non-stop
Embraer ERJ 145 (ER4)
Direct Flights:
American Airlines AA6108
19:44
Philadelphia (PHL) F

22:02
Knoxville (TYS)
Effective 2026-02-17 through 2026-03-04
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:18, non-stop
Embraer ERJ 145 (ER4)
  • A domestic route departing from the Philadelphia airport (PHL) and arriving at Knoxville airport (TYS).
  • The flight distance is 553 miles, or 890 km.
  • The timezone of both the departure and the arrival airports is UTC-5 . Current time at both airports is (loading...).
  • For direct flights, the flight time varies between 1:58 and 2:18.
All PHL-TYS flights
All American Airlines flights
Return (TYS-PHL) flights
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