Delta Air Lines flight DL 6221: Multiple routes

Select flight date:
FLIGHT SCHEDULE
Direct Codeshare Flights:
Wed 00:15 Sao Paulo-Guarulhos (GRU) 2 02:35 Salvador (SSA)
DL 6221 Non-stop Airbus A320 (320) 2:20 Operates only on 2026-04-01
Codeshare flight, operated by LATAM Airlines.(LA 3306)
Wed 00:25 Sao Paulo-Guarulhos (GRU) 2 02:10 Porto Alegre (POA) 1
DL 6221 Non-stop Airbus A321 (321) 1:45 Operates only on 2026-04-08
Codeshare flight, operated by LATAM Airlines.(LA 3147)
Mon 00:30 Sao Paulo-Guarulhos (GRU) 2 03:35 Recife (REC)
DL 6221 Non-stop Airbus A321 (321) 3:05 Operates only on 2026-03-30
Codeshare flight, operated by LATAM Airlines.(LA 3458)
Mon 03:15 Joao Pessoa (JPA) 06:45 Sao Paulo-Guarulhos (GRU) 2
DL 6221 Non-stop Airbus A321 (321) 3:30 Effective 2026-04-06 through 2026-04-27
Codeshare flight, operated by LATAM Airlines.(LA 3387)
Sat 03:55 Sao Paulo-Guarulhos (GRU) 3 06:55 Lima (LIM)
DL 6221 Non-stop Airbus A321 (321) 5:00 Operates only on 2026-01-31
Codeshare flight, operated by LATAM Airlines.(LA 8004)
Sat 03:55 Sao Paulo-Guarulhos (GRU) 3 06:55 Lima (LIM)
DL 6221 Non-stop Airbus A320 (320) 5:00 Operates only on 2026-02-07
Codeshare flight, operated by LATAM Airlines.(LA 8004)
Wed 04:20 Lima (LIM) 05:50 Chiclayo (CIX)
DL 6221 Non-stop Airbus A320 (320) 1:30 Effective 2026-04-15 through 2026-04-22
Codeshare flight, operated by LATAM Airlines.(LA 2270)
Tue 05:25 Cordoba (COR) 07:10 Lima (LIM)
DL 6221 Non-stop Airbus A320 (320) 3:45 Effective 2026-01-13 through 2026-01-27
Codeshare flight, operated by LATAM Airlines.(LA 2385)
Tue 05:25 Cordoba (COR) 07:10 Lima (LIM)
DL 6221 Non-stop Airbus A319 (319) 3:45 Operates only on 2026-02-03
Codeshare flight, operated by LATAM Airlines.(LA 2385)
Tue 05:25 Cordoba (COR) 07:10 Lima (LIM)
DL 6221 Non-stop Airbus A320 (320) 3:45 Effective 2026-02-10 through 2026-02-24
Codeshare flight, operated by LATAM Airlines.(LA 2385)
Fri 05:25 Recife (REC) 08:40 Sao Paulo-Guarulhos (GRU) 2
DL 6221 Non-stop Airbus A321 (321) 3:15 Operates only on 2026-04-03
Codeshare flight, operated by LATAM Airlines.(LA 3379)
Tue 05:30 Medellin Jose Maria Cordova Intl (MDE) 06:35 Bogota (BOG) 1
DL 6221 Non-stop Airbus A320 (320) 1:05 Effective from 2026-10-27
Codeshare flight, operated by LATAM Airlines.(LA 4003)
Wed 06:00 Salvador (SSA) 08:30 Sao Paulo-Guarulhos (GRU) 2
DL 6221 Non-stop Airbus A320 (320) 2:30 Effective 2026-06-17 through 2026-09-30
Codeshare flight, operated by LATAM Airlines.(LA 4675)
Mon 07:05 Sao Paulo-Guarulhos (GRU) 2 09:00 Porto Seguro (BPS)
DL 6221 Non-stop Airbus A320 (320) 1:55 Operates only on 2026-01-26
Codeshare flight, operated by LATAM Airlines.(LA 3240)
Mon 07:05 Sao Paulo-Guarulhos (GRU) 2 09:00 Porto Seguro (BPS)
DL 6221 Non-stop Airbus A320 (320) 1:55 Effective 2026-02-16 through 2026-03-02
Codeshare flight, operated by LATAM Airlines.(LA 3240)
Wed 07:20 Sao Paulo-Guarulhos (GRU) 2 09:20 Ilheus (IOS)
DL 6221 Non-stop Airbus A320 (320) 2:00 Operates only on 2026-06-03
Codeshare flight, operated by LATAM Airlines.(LA 3254)
Sat,Sun 07:25 Sao Paulo-Guarulhos (GRU) 2 09:10 Brasilia (BSB)
DL 6221 Non-stop Airbus A321 (321) 1:45 Effective 2026-04-04 through 2026-10-24
Codeshare flight, operated by LATAM Airlines.(LA 4676)
Thu 07:45 Sao Paulo-Guarulhos (GRU) 2 11:05 Fortaleza (FOR)
DL 6221 Non-stop Airbus A321 (321) 3:20 Operates only on 2026-02-26
Codeshare flight, operated by LATAM Airlines.(LA 3020)
Tue 07:50 Montevideo (MVD) 10:40 Lima (LIM)
DL 6221 Non-stop Airbus A319 (319) 4:50 Operates only on 2026-03-03
Codeshare flight, operated by LATAM Airlines.(LA 2421)
Tue 08:00 Rio de Janeiro Galeao (GIG) 2 11:30 Lima (LIM)
DL 6221 Non-stop Airbus A320 (320) 5:30 Operates only on 2026-01-06
Codeshare flight, operated by LATAM Airlines.(LA 2475)
Wed 08:05 Sao Paulo-Guarulhos (GRU) 2 11:15 Teresina (THE)
DL 6221 Non-stop Airbus A321 (321) 3:10 Effective 2026-05-06 through 2026-05-13
Codeshare flight, operated by LATAM Airlines.(LA 3842)
Wed 09:40 Sao Paulo-Guarulhos (GRU) 2 13:20 Belem (BEL)
DL 6221 Non-stop Airbus A321 (321) 3:40 Effective 2026-03-11 through 2026-03-25
Codeshare flight, operated by LATAM Airlines.(LA 4596)
Thu 09:45 Sao Paulo-Guarulhos (GRU) 2 12:05 Salvador (SSA)
DL 6221 Non-stop Airbus A321 (321) 2:20 Operates only on 2026-01-01
Codeshare flight, operated by LATAM Airlines.(LA 4722)
Sat 09:45 Sao Paulo-Guarulhos (GRU) 2 11:25 Brasilia (BSB)
DL 6221 Non-stop Airbus A321 (321) 1:40 Operates only on 2026-03-07
Codeshare flight, operated by LATAM Airlines.(LA 3263)
Wed 10:12 Cartagena (CTG) 11:50 Bogota (BOG) 1
DL 6221 Non-stop Airbus A320 (320) 1:38 Effective 2026-02-11 through 2026-03-04
Codeshare flight, operated by LATAM Airlines.(LA 4101)
Fri 10:15 Londrina (LDB) 11:25 Sao Paulo-Guarulhos (GRU) 2
DL 6221 Non-stop Airbus A319 (319) 1:10 Effective from 2026-10-30
Codeshare flight, operated by LATAM Airlines.(LA 3459)
Thu 11:35 Sao Paulo-Guarulhos (GRU) 2 12:20 Campo Grande (CGR)
DL 6221 Non-stop Airbus A321 (321) 1:45 Operates only on 2026-02-19
Codeshare flight, operated by LATAM Airlines.(LA 3886)
Sat 12:35 Bogota (BOG) 1 13:34 Pereira (PEI)
DL 6221 Non-stop Airbus A320 (320) 0:59 Operates only on 2026-01-03
Codeshare flight, operated by LATAM Airlines.(LA 4214)
Wed 12:42 Cartagena (CTG) 14:15 Bogota (BOG) 1
DL 6221 Non-stop Airbus A320 (320) 1:33 Valid until 2026-01-21
Codeshare flight, operated by LATAM Airlines.(LA 4101)
Wed 13:15 Sao Paulo-Guarulhos (GRU) 2 14:30 Florianopolis (FLN)
DL 6221 Non-stop Airbus A320 (320) 1:15 Effective 2026-01-28 through 2026-02-04
Codeshare flight, operated by LATAM Airlines.(LA 3302)
Thu 13:20 Sao Paulo-Guarulhos (GRU) 2 14:20 Rio de Janeiro Galeao (GIG) 2
DL 6221 Non-stop Airbus A320 (320) 1:00 Effective 2026-01-08 through 2026-01-15
Codeshare flight, operated by LATAM Airlines.(LA 3366)
Wed 13:25 Lima (LIM) 15:00 Chiclayo (CIX)
DL 6221 Non-stop Airbus A320 (320) 1:35 Operates only on 2026-04-29
Codeshare flight, operated by LATAM Airlines.(LA 2312)
Tue 14:00 Navegantes (NVT) 15:20 Sao Paulo-Guarulhos (GRU) 2
DL 6221 Non-stop Airbus A320 (320) 1:20 Effective 2026-03-10 through 2026-03-24
Codeshare flight, operated by LATAM Airlines.(LA 4609)
Thu 14:30 Rio de Janeiro Galeao (GIG) 2 15:35 Vitoria (VIX)
DL 6221 Non-stop Airbus A320 (320) 1:05 Effective 2026-03-19 through 2026-03-26
Codeshare flight, operated by LATAM Airlines.(LA 3666)
Wed 15:05 Sao Paulo-Guarulhos (GRU) 2 17:55 Maceio (MCZ)
DL 6221 Non-stop Airbus A321 (321) 2:50 Effective 2026-05-20 through 2026-05-27
Codeshare flight, operated by LATAM Airlines.(LA 3448)
Wed 15:05 Sao Paulo-Guarulhos (GRU) 2 17:55 Maceio (MCZ)
DL 6221 Non-stop Airbus A321 (321) 2:50 Operates only on 2026-06-10
Codeshare flight, operated by LATAM Airlines.(LA 3448)
Sat 15:15 Sao Paulo-Guarulhos (GRU) 2 17:20 Porto Seguro (BPS)
DL 6221 Non-stop Airbus A319 (319) 2:05 Operates only on 2026-03-14
Codeshare flight, operated by LATAM Airlines.(LA 3244)
Sat 15:15 Sao Paulo-Guarulhos (GRU) 2 17:20 Porto Seguro (BPS)
DL 6221 Non-stop Airbus A321 (321) 2:05 Effective 2026-03-21 through 2026-03-28
Codeshare flight, operated by LATAM Airlines.(LA 3244)
Mon,Thu 15:30 Lima (LIM) 16:45 Trujillo (TRU)
DL 6221 Non-stop Airbus A320 (320) 1:15 Effective 2026-10-26 through 2026-10-29
Codeshare flight, operated by LATAM Airlines.(LA 2135)
Sat 16:10 Sao Paulo-Guarulhos (GRU) 2 18:45 Aracaju (AJU)
DL 6221 Non-stop Airbus A321 (321) 2:35 Operates only on 2026-01-24
Codeshare flight, operated by LATAM Airlines.(LA 3744)
Sat 16:10 Sao Paulo-Guarulhos (GRU) 2 18:45 Aracaju (AJU)
DL 6221 Non-stop Airbus A321 (321) 2:35 Effective 2026-02-14 through 2026-02-28
Codeshare flight, operated by LATAM Airlines.(LA 3744)
Mon 17:30 Sao Paulo-Guarulhos (GRU) 2 18:30 Rio de Janeiro Galeao (GIG) 2
DL 6221 Non-stop Airbus A321 (321) 1:00 Operates only on 2026-02-02
Codeshare flight, operated by LATAM Airlines.(LA 3874)
Mon 17:30 Sao Paulo-Guarulhos (GRU) 2 18:30 Rio de Janeiro Galeao (GIG) 2
DL 6221 Non-stop Airbus A320 (320) 1:00 Operates only on 2026-02-09
Codeshare flight, operated by LATAM Airlines.(LA 3874)
Thu 17:44 Calama (CJC) 19:50 Santiago (SCL)
DL 6221 Non-stop Airbus A321 (321) 2:06 Effective 2026-04-02 through 2026-10-22
Codeshare flight, operated by LATAM Airlines.(LA 157)
Thu 17:51 Calama (CJC) 19:55 Santiago (SCL)
DL 6221 Non-stop Airbus A321 (321) 2:04 Operates only on 2026-01-29
Codeshare flight, operated by LATAM Airlines.(LA 157)
Thu 17:56 Calama (CJC) 20:00 Santiago (SCL)
DL 6221 Non-stop Airbus A321 (321) 2:04 Operates only on 2026-02-05
Codeshare flight, operated by LATAM Airlines.(LA 157)
Thu 18:00 Rio de Janeiro Galeao (GIG) 2 19:45 Brasilia (BSB)
DL 6221 Non-stop Airbus A320 (320) 1:45 Operates only on 2026-03-05
Codeshare flight, operated by LATAM Airlines.(LA 3729)
Tue 19:29 Calama (CJC) 21:35 Santiago (SCL)
DL 6221 Non-stop Airbus A321 (321) 2:06 Effective 2026-03-31 through 2026-10-20
Codeshare flight, operated by LATAM Airlines.(LA 157)
Fri 20:05 Rio de Janeiro Santos Dumont (SDU) 21:20 Sao Paulo-Guarulhos (GRU) 2
DL 6221 Non-stop Airbus A319 (319) 1:15 Valid until 2026-03-27
Codeshare flight, operated by LATAM Airlines.(LA 4714)
Fri 20:20 Rio de Janeiro Santos Dumont (SDU) 21:30 Sao Paulo-Guarulhos (GRU) 2
DL 6221 Non-stop Airbus A319 (319) 1:10 Effective 2026-04-10 through 2026-10-02
Codeshare flight, operated by LATAM Airlines.(LA 4714)
Wed,Fri 20:20 Rio de Janeiro Santos Dumont (SDU) 21:30 Sao Paulo-Guarulhos (GRU) 2
DL 6221 Non-stop Airbus A319 (319) 1:10 Effective 2026-10-07 through 2026-10-23
Codeshare flight, operated by LATAM Airlines.(LA 4714)
Sun 21:15 Trujillo (TRU) 22:20 Lima (LIM)
DL 6221 Non-stop Airbus A320 (320) 1:05 Valid until 2026-01-25
Codeshare flight, operated by LATAM Airlines.(LA 2138)
Sun 21:15 Trujillo (TRU) 22:25 Lima (LIM)
DL 6221 Non-stop Airbus A320 (320) 1:10 Effective 2026-02-01 through 2026-03-15
Codeshare flight, operated by LATAM Airlines.(LA 2138)
Sun 21:15 Trujillo (TRU) 22:25 Lima (LIM)
DL 6221 Non-stop Airbus A319 (319) 1:10 Operates only on 2026-03-22
Codeshare flight, operated by LATAM Airlines.(LA 2138)
Sun 21:45 Pereira (PEI) 22:40 Bogota (BOG) 1
DL 6221 Non-stop Airbus A320 (320) 0:55 Operates only on 2026-03-29
Codeshare flight, operated by LATAM Airlines.(LA 4259)
Thu 22:10 Sao Paulo-Guarulhos (GRU) 2 23:55 Porto Alegre (POA) 1
DL 6221 Non-stop Airbus A320 (320) 1:45 Operates only on 2026-03-12
Codeshare flight, operated by LATAM Airlines.(LA 3418)
Sat 22:40 Sao Paulo-Guarulhos (GRU) 2 23:50 Navegantes (NVT)
DL 6221 Non-stop Airbus A320 (320) 1:10 Effective 2026-01-10 through 2026-01-17
Codeshare flight, operated by LATAM Airlines.(LA 3304)
Wed,Sun 22:55 Sao Paulo-Guarulhos (GRU) 2 00:40 Porto Alegre (POA) 1
DL 6221 Non-stop Airbus A321 (321) 1:45 Effective from 2026-10-25
Codeshare flight, operated by LATAM Airlines.(LA 3426)
The flight arrives 1 day after departure.
Mon 23:25 Sao Paulo-Guarulhos (GRU) 2 02:00 Aracaju (AJU)
DL 6221 Non-stop Airbus A320 (320) 2:35 Valid until 2026-01-19
Codeshare flight, operated by LATAM Airlines.(LA 3224)
The flight arrives 1 day after departure.
Mon 23:25 Sao Paulo-Guarulhos (GRU) 2 02:00 Aracaju (AJU)
DL 6221 Non-stop Airbus A320 (320) 2:35 Effective 2026-03-09 through 2026-03-23
Codeshare flight, operated by LATAM Airlines.(LA 3224)
The flight arrives 1 day after departure.
Mon 23:25 Sao Paulo-Guarulhos (GRU) 2 02:00 Aracaju (AJU)
DL 6221 Non-stop Airbus A321 (321) 2:35 Effective 2026-05-04 through 2026-10-19
Codeshare flight, operated by LATAM Airlines.(LA 3224)
The flight arrives 1 day after departure.
Thu 23:50 Sao Paulo-Guarulhos (GRU) 2 01:05 Cuiaba (CGB)
DL 6221 Non-stop Airbus A321 (321) 2:15 Operates only on 2026-01-22
Codeshare flight, operated by LATAM Airlines.(LA 3566)
The flight arrives 1 day after departure.
Thu 23:50 Sao Paulo-Guarulhos (GRU) 2 01:05 Cuiaba (CGB)
DL 6221 Non-stop Airbus A321 (321) 2:15 Operates only on 2026-02-12
Codeshare flight, operated by LATAM Airlines.(LA 3566)
The flight arrives 1 day after departure.
This flight number is listed as serving the following routes:


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Delta Air Lines flight DL 6221: Multiple routes
Select flight date:
FLIGHT SCHEDULE
Direct Codeshare Flights:
Delta Air Lines DL6221
00:15
Sao Paulo-Guarulhos (GRU) 2

02:35
Salvador (SSA)
Operates only on 2026-04-01
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3306)
Duration: 2:20, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
00:25
Sao Paulo-Guarulhos (GRU) 2

02:10
Porto Alegre (POA) 1
Operates only on 2026-04-08
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3147)
Duration: 1:45, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
00:30
Sao Paulo-Guarulhos (GRU) 2

03:35
Recife (REC)
Operates only on 2026-03-30
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3458)
Duration: 3:05, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
03:15
Joao Pessoa (JPA)

06:45
Sao Paulo-Guarulhos (GRU) 2
Effective 2026-04-06 through 2026-04-27
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3387)
Duration: 3:30, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
03:55
Sao Paulo-Guarulhos (GRU) 3

06:55
Lima (LIM)
Operates only on 2026-01-31
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 8004)
Duration: 5:00, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
03:55
Sao Paulo-Guarulhos (GRU) 3

06:55
Lima (LIM)
Operates only on 2026-02-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 8004)
Duration: 5:00, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
04:20
Lima (LIM)

05:50
Chiclayo (CIX)
Effective 2026-04-15 through 2026-04-22
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 2270)
Duration: 1:30, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
05:25
Cordoba (COR)

07:10
Lima (LIM)
Effective 2026-01-13 through 2026-01-27
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 2385)
Duration: 3:45, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
05:25
Cordoba (COR)

07:10
Lima (LIM)
Operates only on 2026-02-03
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 2385)
Duration: 3:45, non-stop
Airbus A319 (319)
Direct Codeshare Flights:
Delta Air Lines DL6221
05:25
Cordoba (COR)

07:10
Lima (LIM)
Effective 2026-02-10 through 2026-02-24
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 2385)
Duration: 3:45, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
05:25
Recife (REC)

08:40
Sao Paulo-Guarulhos (GRU) 2
Operates only on 2026-04-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3379)
Duration: 3:15, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
05:30
Medellin Jose Maria Cordova Intl (MDE)

06:35
Bogota (BOG) 1
Effective from 2026-10-27
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 4003)
Duration: 1:05, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
06:00
Salvador (SSA)

08:30
Sao Paulo-Guarulhos (GRU) 2
Effective 2026-06-17 through 2026-09-30
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 4675)
Duration: 2:30, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
07:05
Sao Paulo-Guarulhos (GRU) 2

09:00
Porto Seguro (BPS)
Operates only on 2026-01-26
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3240)
Duration: 1:55, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
07:05
Sao Paulo-Guarulhos (GRU) 2

09:00
Porto Seguro (BPS)
Effective 2026-02-16 through 2026-03-02
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3240)
Duration: 1:55, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
07:20
Sao Paulo-Guarulhos (GRU) 2

09:20
Ilheus (IOS)
Operates only on 2026-06-03
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3254)
Duration: 2:00, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
07:25
Sao Paulo-Guarulhos (GRU) 2

09:10
Brasilia (BSB)
Effective 2026-04-04 through 2026-10-24
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
Codeshare flight, operated by LATAM Airlines. (LA 4676)
Duration: 1:45, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
07:45
Sao Paulo-Guarulhos (GRU) 2

11:05
Fortaleza (FOR)
Operates only on 2026-02-26
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3020)
Duration: 3:20, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
07:50
Montevideo (MVD)

10:40
Lima (LIM)
Operates only on 2026-03-03
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 2421)
Duration: 4:50, non-stop
Airbus A319 (319)
Direct Codeshare Flights:
Delta Air Lines DL6221
08:00
Rio de Janeiro Galeao (GIG) 2

11:30
Lima (LIM)
Operates only on 2026-01-06
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 2475)
Duration: 5:30, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
08:05
Sao Paulo-Guarulhos (GRU) 2

11:15
Teresina (THE)
Effective 2026-05-06 through 2026-05-13
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3842)
Duration: 3:10, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
09:40
Sao Paulo-Guarulhos (GRU) 2

13:20
Belem (BEL)
Effective 2026-03-11 through 2026-03-25
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 4596)
Duration: 3:40, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
09:45
Sao Paulo-Guarulhos (GRU) 2

12:05
Salvador (SSA)
Operates only on 2026-01-01
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 4722)
Duration: 2:20, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
09:45
Sao Paulo-Guarulhos (GRU) 2

11:25
Brasilia (BSB)
Operates only on 2026-03-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3263)
Duration: 1:40, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
10:12
Cartagena (CTG)

11:50
Bogota (BOG) 1
Effective 2026-02-11 through 2026-03-04
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 4101)
Duration: 1:38, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
10:15
Londrina (LDB)

11:25
Sao Paulo-Guarulhos (GRU) 2
Effective from 2026-10-30
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3459)
Duration: 1:10, non-stop
Airbus A319 (319)
Direct Codeshare Flights:
Delta Air Lines DL6221
11:35
Sao Paulo-Guarulhos (GRU) 2

12:20
Campo Grande (CGR)
Operates only on 2026-02-19
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3886)
Duration: 1:45, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
12:35
Bogota (BOG) 1

13:34
Pereira (PEI)
Operates only on 2026-01-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 4214)
Duration: 0:59, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
12:42
Cartagena (CTG)

14:15
Bogota (BOG) 1
Valid until 2026-01-21
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 4101)
Duration: 1:33, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
13:15
Sao Paulo-Guarulhos (GRU) 2

14:30
Florianopolis (FLN)
Effective 2026-01-28 through 2026-02-04
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3302)
Duration: 1:15, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
13:20
Sao Paulo-Guarulhos (GRU) 2

14:20
Rio de Janeiro Galeao (GIG) 2
Effective 2026-01-08 through 2026-01-15
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3366)
Duration: 1:00, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
13:25
Lima (LIM)

15:00
Chiclayo (CIX)
Operates only on 2026-04-29
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 2312)
Duration: 1:35, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
14:00
Navegantes (NVT)

15:20
Sao Paulo-Guarulhos (GRU) 2
Effective 2026-03-10 through 2026-03-24
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 4609)
Duration: 1:20, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
14:30
Rio de Janeiro Galeao (GIG) 2

15:35
Vitoria (VIX)
Effective 2026-03-19 through 2026-03-26
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3666)
Duration: 1:05, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
15:05
Sao Paulo-Guarulhos (GRU) 2

17:55
Maceio (MCZ)
Effective 2026-05-20 through 2026-05-27
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3448)
Duration: 2:50, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
15:05
Sao Paulo-Guarulhos (GRU) 2

17:55
Maceio (MCZ)
Operates only on 2026-06-10
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3448)
Duration: 2:50, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
15:15
Sao Paulo-Guarulhos (GRU) 2

17:20
Porto Seguro (BPS)
Operates only on 2026-03-14
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3244)
Duration: 2:05, non-stop
Airbus A319 (319)
Direct Codeshare Flights:
Delta Air Lines DL6221
15:15
Sao Paulo-Guarulhos (GRU) 2

17:20
Porto Seguro (BPS)
Effective 2026-03-21 through 2026-03-28
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3244)
Duration: 2:05, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
15:30
Lima (LIM)

16:45
Trujillo (TRU)
Effective 2026-10-26 through 2026-10-29
Mon
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 2135)
Duration: 1:15, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
16:10
Sao Paulo-Guarulhos (GRU) 2

18:45
Aracaju (AJU)
Operates only on 2026-01-24
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3744)
Duration: 2:35, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
16:10
Sao Paulo-Guarulhos (GRU) 2

18:45
Aracaju (AJU)
Effective 2026-02-14 through 2026-02-28
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3744)
Duration: 2:35, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
17:30
Sao Paulo-Guarulhos (GRU) 2

18:30
Rio de Janeiro Galeao (GIG) 2
Operates only on 2026-02-02
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3874)
Duration: 1:00, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
17:30
Sao Paulo-Guarulhos (GRU) 2

18:30
Rio de Janeiro Galeao (GIG) 2
Operates only on 2026-02-09
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3874)
Duration: 1:00, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
17:44
Calama (CJC)

19:50
Santiago (SCL)
Effective 2026-04-02 through 2026-10-22
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 157)
Duration: 2:06, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
17:51
Calama (CJC)

19:55
Santiago (SCL)
Operates only on 2026-01-29
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 157)
Duration: 2:04, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
17:56
Calama (CJC)

20:00
Santiago (SCL)
Operates only on 2026-02-05
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 157)
Duration: 2:04, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
18:00
Rio de Janeiro Galeao (GIG) 2

19:45
Brasilia (BSB)
Operates only on 2026-03-05
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3729)
Duration: 1:45, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
19:29
Calama (CJC)

21:35
Santiago (SCL)
Effective 2026-03-31 through 2026-10-20
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 157)
Duration: 2:06, non-stop
Airbus A321 (321)
Direct Codeshare Flights:
Delta Air Lines DL6221
20:05
Rio de Janeiro Santos Dumont (SDU)

21:20
Sao Paulo-Guarulhos (GRU) 2
Valid until 2026-03-27
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 4714)
Duration: 1:15, non-stop
Airbus A319 (319)
Direct Codeshare Flights:
Delta Air Lines DL6221
20:20
Rio de Janeiro Santos Dumont (SDU)

21:30
Sao Paulo-Guarulhos (GRU) 2
Effective 2026-04-10 through 2026-10-02
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 4714)
Duration: 1:10, non-stop
Airbus A319 (319)
Direct Codeshare Flights:
Delta Air Lines DL6221
20:20
Rio de Janeiro Santos Dumont (SDU)

21:30
Sao Paulo-Guarulhos (GRU) 2
Effective 2026-10-07 through 2026-10-23
Mon
-
Tue
-
Wed
Thu
-
Fri
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 4714)
Duration: 1:10, non-stop
Airbus A319 (319)
Direct Codeshare Flights:
Delta Air Lines DL6221
21:15
Trujillo (TRU)

22:20
Lima (LIM)
Valid until 2026-01-25
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Codeshare flight, operated by LATAM Airlines. (LA 2138)
Duration: 1:05, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
21:15
Trujillo (TRU)

22:25
Lima (LIM)
Effective 2026-02-01 through 2026-03-15
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Codeshare flight, operated by LATAM Airlines. (LA 2138)
Duration: 1:10, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
21:15
Trujillo (TRU)

22:25
Lima (LIM)
Operates only on 2026-03-22
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Codeshare flight, operated by LATAM Airlines. (LA 2138)
Duration: 1:10, non-stop
Airbus A319 (319)
Direct Codeshare Flights:
Delta Air Lines DL6221
21:45
Pereira (PEI)

22:40
Bogota (BOG) 1
Operates only on 2026-03-29
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Codeshare flight, operated by LATAM Airlines. (LA 4259)
Duration: 0:55, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
22:10
Sao Paulo-Guarulhos (GRU) 2

23:55
Porto Alegre (POA) 1
Operates only on 2026-03-12
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3418)
Duration: 1:45, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
22:40
Sao Paulo-Guarulhos (GRU) 2

23:50
Navegantes (NVT)
Effective 2026-01-10 through 2026-01-17
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3304)
Duration: 1:10, non-stop
Airbus A320 (320)
Direct Codeshare Flights:
Delta Air Lines DL6221
22:55
Sao Paulo-Guarulhos (GRU) 2

00:40(+1)
Porto Alegre (POA) 1
Effective from 2026-10-25
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
Codeshare flight, operated by LATAM Airlines. (LA 3426)
Duration: 1:45, non-stop
Airbus A321 (321)
The flight arrives 1 day after departure.
Direct Codeshare Flights:
Delta Air Lines DL6221
23:25
Sao Paulo-Guarulhos (GRU) 2

02:00(+1)
Aracaju (AJU)
Valid until 2026-01-19
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3224)
Duration: 2:35, non-stop
Airbus A320 (320)
The flight arrives 1 day after departure.
Direct Codeshare Flights:
Delta Air Lines DL6221
23:25
Sao Paulo-Guarulhos (GRU) 2

02:00(+1)
Aracaju (AJU)
Effective 2026-03-09 through 2026-03-23
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3224)
Duration: 2:35, non-stop
Airbus A320 (320)
The flight arrives 1 day after departure.
Direct Codeshare Flights:
Delta Air Lines DL6221
23:25
Sao Paulo-Guarulhos (GRU) 2

02:00(+1)
Aracaju (AJU)
Effective 2026-05-04 through 2026-10-19
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3224)
Duration: 2:35, non-stop
Airbus A321 (321)
The flight arrives 1 day after departure.
Direct Codeshare Flights:
Delta Air Lines DL6221
23:50
Sao Paulo-Guarulhos (GRU) 2

01:05(+1)
Cuiaba (CGB)
Operates only on 2026-01-22
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3566)
Duration: 2:15, non-stop
Airbus A321 (321)
The flight arrives 1 day after departure.
Direct Codeshare Flights:
Delta Air Lines DL6221
23:50
Sao Paulo-Guarulhos (GRU) 2

01:05(+1)
Cuiaba (CGB)
Operates only on 2026-02-12
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by LATAM Airlines. (LA 3566)
Duration: 2:15, non-stop
Airbus A321 (321)
The flight arrives 1 day after departure.
This flight number is listed as serving the following routes:
  • Calama (CJC) - Santiago (SCL)
  • Cartagena (CTG) - Bogota (BOG)
  • Cordoba (COR) - Lima (LIM)
  • Joao Pessoa (JPA) - Sao Paulo-Guarulhos (GRU)
  • Lima (LIM) - Chiclayo (CIX)
  • Lima (LIM) - Trujillo (TRU)
  • Londrina (LDB) - Sao Paulo-Guarulhos (GRU)
  • Medellin Jose Maria Cordova Intl (MDE) - Bogota (BOG)
  • Montevideo (MVD) - Lima (LIM)
  • Pereira (PEI) - Bogota (BOG)
  • Rio de Janeiro Galeao (GIG) - Brasilia (BSB)
  • Rio de Janeiro Galeao (GIG) - Lima (LIM)
  • Rio de Janeiro Galeao (GIG) - Vitoria (VIX)
  • Rio de Janeiro Santos Dumont (SDU) - Sao Paulo-Guarulhos (GRU)
  • Salvador (SSA) - Sao Paulo-Guarulhos (GRU)
  • Sao Paulo-Guarulhos (GRU) - Aracaju (AJU)
  • Sao Paulo-Guarulhos (GRU) - Belem (BEL)
  • Sao Paulo-Guarulhos (GRU) - Brasilia (BSB)
  • Sao Paulo-Guarulhos (GRU) - Campo Grande (CGR)
  • Sao Paulo-Guarulhos (GRU) - Cuiaba (CGB)
  • Sao Paulo-Guarulhos (GRU) - Florianopolis (FLN)
  • Sao Paulo-Guarulhos (GRU) - Fortaleza (FOR)
  • Sao Paulo-Guarulhos (GRU) - Ilheus (IOS)
  • Sao Paulo-Guarulhos (GRU) - Lima (LIM)
  • Sao Paulo-Guarulhos (GRU) - Maceio (MCZ)
  • Sao Paulo-Guarulhos (GRU) - Navegantes (NVT)
  • Sao Paulo-Guarulhos (GRU) - Porto Alegre (POA)
  • Sao Paulo-Guarulhos (GRU) - Porto Seguro (BPS)
  • Sao Paulo-Guarulhos (GRU) - Recife (REC)
  • Sao Paulo-Guarulhos (GRU) - Rio de Janeiro Galeao (GIG)
  • Sao Paulo-Guarulhos (GRU) - Teresina (THE)
All Delta Air Lines flights
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