Delta Air Lines flight DL 421: Multiple routes

Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Tue,Fri-Sun 12:15 Detroit (DTW) M 13:43 Las Vegas Harry Reid (LAS) 1
DL 421 Non-stop Airbus A321 (321) 4:28 Valid until 2026-01-04
Daily 12:32 Detroit (DTW) M 14:08 Las Vegas Harry Reid (LAS) 1
DL 421 Non-stop Airbus A321 (321) 4:36 Effective 2026-01-05 through 2026-03-07
Daily 12:35 Detroit (DTW) M 14:09 Las Vegas Harry Reid (LAS) 1
DL 421 Non-stop Airbus A321 (321) 4:34 Effective 2026-03-08 through 2026-04-12
Daily 12:55 Detroit (DTW) M 14:24 Las Vegas Harry Reid (LAS) 1
DL 421 Non-stop Airbus A321 (321) 4:29 Effective 2026-04-13 through 2026-05-06
Daily 12:55 Detroit (DTW) M 14:23 Las Vegas Harry Reid (LAS) 1
DL 421 Non-stop Boeing 757 (757) 4:28 Effective 2026-05-07 through 2026-10-05
Daily 12:55 Detroit (DTW) M 14:27 Las Vegas Harry Reid (LAS) 1
DL 421 Non-stop Boeing 757 (757) 4:32 Effective from 2026-10-06
Daily 14:50 Las Vegas Harry Reid (LAS) 1 21:55 Detroit (DTW) M
DL 421 Non-stop Airbus A321 (321) 4:05 Effective 2026-04-13 through 2026-05-06
Daily 15:20 Las Vegas Harry Reid (LAS) 1 22:20 Detroit (DTW) M
DL 421 Non-stop Airbus A321 (321) 4:00 Effective 2026-01-05 through 2026-03-07
Daily 15:22 Las Vegas Harry Reid (LAS) 1 22:20 Detroit (DTW) M
DL 421 Non-stop Airbus A321 (321) 3:58 Effective 2026-03-08 through 2026-04-12
This flight number is listed as serving the following routes:


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Delta Air Lines flight DL 421: Multiple routes
Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Delta Air Lines DL421
12:15
Detroit (DTW) M

13:43
Las Vegas Harry Reid (LAS) 1
Valid until 2026-01-04
Mon
-
Tue
Wed
-
Thu
-
Fri
Sat
Sun
Duration: 4:28, non-stop
Airbus A321 (321)
Direct Flights:
Delta Air Lines DL421
12:32
Detroit (DTW) M

14:08
Las Vegas Harry Reid (LAS) 1
Effective 2026-01-05 through 2026-03-07
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:36, non-stop
Airbus A321 (321)
Direct Flights:
Delta Air Lines DL421
12:35
Detroit (DTW) M

14:09
Las Vegas Harry Reid (LAS) 1
Effective 2026-03-08 through 2026-04-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:34, non-stop
Airbus A321 (321)
Direct Flights:
Delta Air Lines DL421
12:55
Detroit (DTW) M

14:24
Las Vegas Harry Reid (LAS) 1
Effective 2026-04-13 through 2026-05-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:29, non-stop
Airbus A321 (321)
Direct Flights:
Delta Air Lines DL421
12:55
Detroit (DTW) M

14:23
Las Vegas Harry Reid (LAS) 1
Effective 2026-05-07 through 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:28, non-stop
Boeing 757 (757)
Direct Flights:
Delta Air Lines DL421
12:55
Detroit (DTW) M

14:27
Las Vegas Harry Reid (LAS) 1
Effective from 2026-10-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:32, non-stop
Boeing 757 (757)
Direct Flights:
Delta Air Lines DL421
14:50
Las Vegas Harry Reid (LAS) 1

21:55
Detroit (DTW) M
Effective 2026-04-13 through 2026-05-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:05, non-stop
Airbus A321 (321)
Direct Flights:
Delta Air Lines DL421
15:20
Las Vegas Harry Reid (LAS) 1

22:20
Detroit (DTW) M
Effective 2026-01-05 through 2026-03-07
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:00, non-stop
Airbus A321 (321)
Direct Flights:
Delta Air Lines DL421
15:22
Las Vegas Harry Reid (LAS) 1

22:20
Detroit (DTW) M
Effective 2026-03-08 through 2026-04-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:58, non-stop
Airbus A321 (321)
This flight number is listed as serving the following routes:
  • Detroit (DTW) - Las Vegas Harry Reid (LAS)
All Delta Air Lines flights
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