American Airlines flight AA 643: Multiple routes

Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Sat 08:00 Pittsburgh (PIT) 13:12 Punta Cana (PUJ) B
AA 643 Non-stop Boeing 737 MAX 8 (7M8) 4:12 Operates only on 2026-01-03
Sat 08:00 Pittsburgh (PIT) 13:16 Punta Cana (PUJ) B
AA 643 Non-stop Boeing 737-800 (738) 4:16 Effective 2026-01-10 through 2026-02-07
Sat 08:00 Pittsburgh (PIT) 13:07 Punta Cana (PUJ) B
AA 643 Non-stop Airbus A321 (321) 4:07 Effective 2026-02-14 through 2026-03-07
Sat 14:12 Punta Cana (PUJ) B 17:27 Pittsburgh (PIT)
AA 643 Non-stop Boeing 737 MAX 8 (7M8) 4:15 Operates only on 2026-01-03
Sat 14:25 Punta Cana (PUJ) B 17:52 Pittsburgh (PIT)
AA 643 Non-stop Airbus A321 (321) 4:27 Effective 2026-02-14 through 2026-03-07
Daily 15:35 Miami (MIA) 19:00 Guayaquil (GYE)
AA 643 Non-stop Boeing 737 MAX 8 (7M8) 4:25 Effective 2026-09-09 through 2026-10-04
Daily 15:35 Miami (MIA) 18:55 Guayaquil (GYE)
AA 643 Non-stop Boeing 737 MAX 8 (7M8) 4:20 Effective from 2026-10-05
Daily 16:07 Miami (MIA) 19:37 Guayaquil (GYE)
AA 643 Non-stop Boeing 737 MAX 8 (7M8) 4:30 Effective 2026-08-05 through 2026-09-08
Daily 17:35 Miami (MIA) 20:55 Guayaquil (GYE)
AA 643 Non-stop Boeing 737 MAX 8 (7M8) 4:20 Effective 2026-04-07 through 2026-05-20
Daily 17:35 Miami (MIA) 21:10 Guayaquil (GYE)
AA 643 Non-stop Boeing 737 MAX 8 (7M8) 4:35 Effective 2026-05-21 through 2026-07-01
Daily 17:35 Miami (MIA) 21:05 Guayaquil (GYE)
AA 643 Non-stop Boeing 737 MAX 8 (7M8) 4:30 Effective 2026-07-02 through 2026-08-04
Daily 18:09 Miami (MIA) 21:33 Guayaquil (GYE)
AA 643 Non-stop Boeing 737 MAX 8 (7M8) 4:24 Effective 2026-03-08 through 2026-04-06
This flight number is listed as serving the following routes:


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American Airlines flight AA 643: Multiple routes
Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA643
08:00
Pittsburgh (PIT)

13:12
Punta Cana (PUJ) B
Operates only on 2026-01-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 4:12, non-stop
Boeing 737 MAX 8 (7M8)
Direct Flights:
American Airlines AA643
08:00
Pittsburgh (PIT)

13:16
Punta Cana (PUJ) B
Effective 2026-01-10 through 2026-02-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 4:16, non-stop
Boeing 737-800 (738)
Direct Flights:
American Airlines AA643
08:00
Pittsburgh (PIT)

13:07
Punta Cana (PUJ) B
Effective 2026-02-14 through 2026-03-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 4:07, non-stop
Airbus A321 (321)
Direct Flights:
American Airlines AA643
14:12
Punta Cana (PUJ) B

17:27
Pittsburgh (PIT)
Operates only on 2026-01-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 4:15, non-stop
Boeing 737 MAX 8 (7M8)
Direct Flights:
American Airlines AA643
14:25
Punta Cana (PUJ) B

17:52
Pittsburgh (PIT)
Effective 2026-02-14 through 2026-03-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 4:27, non-stop
Airbus A321 (321)
Direct Flights:
American Airlines AA643
15:35
Miami (MIA)

19:00
Guayaquil (GYE)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:25, non-stop
Boeing 737 MAX 8 (7M8)
Direct Flights:
American Airlines AA643
15:35
Miami (MIA)

18:55
Guayaquil (GYE)
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:20, non-stop
Boeing 737 MAX 8 (7M8)
Direct Flights:
American Airlines AA643
16:07
Miami (MIA)

19:37
Guayaquil (GYE)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:30, non-stop
Boeing 737 MAX 8 (7M8)
Direct Flights:
American Airlines AA643
17:35
Miami (MIA)

20:55
Guayaquil (GYE)
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:20, non-stop
Boeing 737 MAX 8 (7M8)
Direct Flights:
American Airlines AA643
17:35
Miami (MIA)

21:10
Guayaquil (GYE)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:35, non-stop
Boeing 737 MAX 8 (7M8)
Direct Flights:
American Airlines AA643
17:35
Miami (MIA)

21:05
Guayaquil (GYE)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:30, non-stop
Boeing 737 MAX 8 (7M8)
Direct Flights:
American Airlines AA643
18:09
Miami (MIA)

21:33
Guayaquil (GYE)
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:24, non-stop
Boeing 737 MAX 8 (7M8)
This flight number is listed as serving the following routes:
  • Miami (MIA) - Guayaquil (GYE)
  • Pittsburgh (PIT) - Punta Cana (PUJ)
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