American Airlines flight AA 4385: Multiple routes

Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Sat 07:00 New York LaGuardia (LGA) B 08:56 Raleigh/Durham (RDU) 2
AA 4385 Non-stop Embraer EMB 175 (E75) 1:56 Valid until 2026-01-03
Sat 07:30 New York LaGuardia (LGA) B 09:21 Raleigh/Durham (RDU) 2
AA 4385 Non-stop Embraer EMB 175 (E75) 1:51 Effective 2026-01-10 through 2026-02-07
Sat 07:40 New York LaGuardia (LGA) B 09:34 Raleigh/Durham (RDU) 2
AA 4385 Non-stop Embraer EMB 175 (E75) 1:54 Effective 2026-02-14 through 2026-03-07
Mon-Fri,Sun 08:06 Chicago O'Hare (ORD) 3 09:14 Madison (MSN)
AA 4385 Non-stop Embraer EMB 175 (E75) 1:08 Effective 2026-03-08 through 2026-04-06
Mon-Fri,Sun 08:08 Chicago O'Hare (ORD) 3 09:13 Madison (MSN)
AA 4385 Non-stop Embraer EMB 175 (E75) 1:05 Effective 2026-02-13 through 2026-03-06
Mon-Fri,Sun 08:09 New York LaGuardia (LGA) B 10:00 Raleigh/Durham (RDU) 2
AA 4385 Non-stop Embraer EMB 175 (E75) 1:51 Effective 2026-01-07 through 2026-02-11
Thu 08:10 Chicago O'Hare (ORD) 3 09:15 Madison (MSN)
AA 4385 Non-stop Embraer EMB 175 (E75) 1:05 Operates only on 2026-02-12
Tue 09:00 Chicago O'Hare (ORD) 3 11:29 John Glenn Columbus (CMH)
AA 4385 Non-stop Embraer EMB 175 (E75) 1:29 Operates only on 2026-01-06
Mon-Fri,Sun 09:43 Madison (MSN) 10:54 Chicago O'Hare (ORD) 3
AA 4385 Non-stop Embraer EMB 175 (E75) 1:11 Effective 2026-02-13 through 2026-03-06
Mon-Fri,Sun 09:44 Madison (MSN) 10:54 Chicago O'Hare (ORD) 3
AA 4385 Non-stop Embraer EMB 175 (E75) 1:10 Effective 2026-03-08 through 2026-04-06
Thu 09:45 Madison (MSN) 10:56 Chicago O'Hare (ORD) 3
AA 4385 Non-stop Embraer EMB 175 (E75) 1:11 Operates only on 2026-02-12
Daily 09:50 Indianapolis (IND) 12:07 Boston Logan (BOS) B
AA 4385 Non-stop Embraer EMB 175 (E75) 2:17 Effective from 2026-10-05
Daily 11:29 New York John F. Kennedy (JFK) 8 13:40 Indianapolis (IND)
AA 4385 Non-stop Embraer EMB 175 (E75) 2:11 Effective 2026-05-21 through 2026-07-01
Daily 11:29 New York John F. Kennedy (JFK) 8 13:46 Indianapolis (IND)
AA 4385 Non-stop Embraer EMB 175 (E75) 2:17 Effective 2026-07-02 through 2026-08-04
Daily 11:46 New York John F. Kennedy (JFK) 8 14:03 Indianapolis (IND)
AA 4385 Non-stop Embraer EMB 175 (E75) 2:17 Effective 2026-08-05 through 2026-09-08
Daily 12:00 New York LaGuardia (LGA) B 13:46 Greensboro/High Point (GSO)
AA 4385 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:46 Effective 2026-09-09 through 2026-10-04
Daily 13:09 New York LaGuardia (LGA) B 14:33 Buffalo (BUF)
AA 4385 Non-stop Embraer EMB 175 (E75) 1:24 Effective 2026-05-07 through 2026-05-20
Daily 14:19 Greensboro/High Point (GSO) 15:55 New York LaGuardia (LGA) B
AA 4385 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:36 Effective 2026-09-09 through 2026-10-04
Daily 16:06 Buffalo (BUF) 17:28 New York LaGuardia (LGA) B
AA 4385 Non-stop Embraer EMB 175 (E75) 1:22 Effective 2026-05-07 through 2026-05-20
Daily 16:10 New York LaGuardia (LGA) B 17:58 Buffalo (BUF)
AA 4385 Non-stop Embraer EMB 175 (E75) 1:48 Effective 2026-04-07 through 2026-05-06
Daily 18:20 Buffalo (BUF) 19:41 New York LaGuardia (LGA) B
AA 4385 Non-stop Embraer EMB 175 (E75) 1:21 Effective 2026-04-07 through 2026-05-06
Mon 19:48 Chicago O'Hare (ORD) 3 22:25 Cincinnati (CVG)
AA 4385 Non-stop Embraer EMB 175 (E75) 1:37 Operates only on 2026-01-05
This flight number is listed as serving the following routes:


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American Airlines flight AA 4385: Multiple routes
Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4385
07:00
New York LaGuardia (LGA) B

08:56
Raleigh/Durham (RDU) 2
Valid until 2026-01-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
07:30
New York LaGuardia (LGA) B

09:21
Raleigh/Durham (RDU) 2
Effective 2026-01-10 through 2026-02-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:51, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
07:40
New York LaGuardia (LGA) B

09:34
Raleigh/Durham (RDU) 2
Effective 2026-02-14 through 2026-03-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:54, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
08:06
Chicago O'Hare (ORD) 3

09:14
Madison (MSN)
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:08, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
08:08
Chicago O'Hare (ORD) 3

09:13
Madison (MSN)
Effective 2026-02-13 through 2026-03-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:05, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
08:09
New York LaGuardia (LGA) B

10:00
Raleigh/Durham (RDU) 2
Effective 2026-01-07 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:51, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
08:10
Chicago O'Hare (ORD) 3

09:15
Madison (MSN)
Operates only on 2026-02-12
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Duration: 1:05, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
09:00
Chicago O'Hare (ORD) 3

11:29
John Glenn Columbus (CMH)
Operates only on 2026-01-06
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 1:29, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
09:43
Madison (MSN)

10:54
Chicago O'Hare (ORD) 3
Effective 2026-02-13 through 2026-03-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:11, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
09:44
Madison (MSN)

10:54
Chicago O'Hare (ORD) 3
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:10, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
09:45
Madison (MSN)

10:56
Chicago O'Hare (ORD) 3
Operates only on 2026-02-12
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Duration: 1:11, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
09:50
Indianapolis (IND)

12:07
Boston Logan (BOS) B
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:17, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
11:29
New York John F. Kennedy (JFK) 8

13:40
Indianapolis (IND)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:11, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
11:29
New York John F. Kennedy (JFK) 8

13:46
Indianapolis (IND)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:17, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
11:46
New York John F. Kennedy (JFK) 8

14:03
Indianapolis (IND)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:17, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
12:00
New York LaGuardia (LGA) B

13:46
Greensboro/High Point (GSO)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:46, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4385
13:09
New York LaGuardia (LGA) B

14:33
Buffalo (BUF)
Effective 2026-05-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:24, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
14:19
Greensboro/High Point (GSO)

15:55
New York LaGuardia (LGA) B
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:36, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4385
16:06
Buffalo (BUF)

17:28
New York LaGuardia (LGA) B
Effective 2026-05-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:22, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
16:10
New York LaGuardia (LGA) B

17:58
Buffalo (BUF)
Effective 2026-04-07 through 2026-05-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:48, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
18:20
Buffalo (BUF)

19:41
New York LaGuardia (LGA) B
Effective 2026-04-07 through 2026-05-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:21, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4385
19:48
Chicago O'Hare (ORD) 3

22:25
Cincinnati (CVG)
Operates only on 2026-01-05
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 1:37, non-stop
Embraer EMB 175 (E75)
This flight number is listed as serving the following routes:
  • Buffalo (BUF) - New York LaGuardia (LGA)
  • Chicago O'Hare (ORD) - Cincinnati (CVG)
  • Chicago O'Hare (ORD) - John Glenn Columbus (CMH)
  • Greensboro/High Point (GSO) - New York LaGuardia (LGA)
  • Indianapolis (IND) - Boston Logan (BOS)
  • Madison (MSN) - Chicago O'Hare (ORD)
  • New York John F. Kennedy (JFK) - Indianapolis (IND)
  • New York LaGuardia (LGA) - Raleigh/Durham (RDU)
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