American Airlines flight AA 4353: Multiple routes

Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 08:30 New York LaGuardia (LGA) B 09:41 Boston Logan (BOS) B
AA 4353 Non-stop Embraer EMB 175 (E75) 1:11 Effective from 2026-10-05
Sat,Sun 09:00 Ronald Reagan Washington (DCA) 2 10:54 Cincinnati (CVG)
AA 4353 Non-stop Embraer EMB 175 (E75) 1:54 Effective 2026-02-14 through 2026-03-07
Mon-Fri,Sun 09:30 Philadelphia (PHL) 11:44 Indianapolis (IND)
AA 4353 Non-stop Embraer EMB 175 (E75) 2:14 Effective 2026-03-08 through 2026-04-06
Sat 09:34 Philadelphia (PHL) 11:48 Indianapolis (IND)
AA 4353 Non-stop Embraer EMB 175 (E75) 2:14 Effective 2026-03-14 through 2026-04-04
Sat,Sun 11:24 Cincinnati (CVG) 12:54 Ronald Reagan Washington (DCA) 2
AA 4353 Non-stop Embraer EMB 175 (E75) 1:30 Effective 2026-02-14 through 2026-03-07
Daily 11:35 New York LaGuardia (LGA) B 13:46 Asheville/Hendersonville (AVL)
AA 4353 Non-stop Embraer EMB 175 (E75) 2:11 Effective 2026-07-02 through 2026-08-04
Daily 13:35 Philadelphia (PHL) 15:17 Bangor (BGR)
AA 4353 Non-stop Embraer EMB 175 (E75) 1:42 Effective 2026-05-21 through 2026-07-01
Mon,Tue,Thu-Sun 13:45 Chicago O'Hare (ORD) 3 16:23 New Orleans (MSY)
AA 4353 Non-stop Embraer EMB 175 (E75) 2:38 Valid until 2026-01-05
Daily 14:23 Asheville/Hendersonville (AVL) 16:18 New York LaGuardia (LGA) B
AA 4353 Non-stop Embraer EMB 175 (E75) 1:55 Effective 2026-07-02 through 2026-08-04
Daily 15:59 Bangor (BGR) 17:55 Philadelphia (PHL)
AA 4353 Non-stop Embraer EMB 175 (E75) 1:56 Effective 2026-05-21 through 2026-07-01
Sun 16:25 New York LaGuardia (LGA) B 18:55 Atlanta (ATL) N
AA 4353 Non-stop Embraer EMB 175 (E75) 2:30 Effective 2026-08-09 through 2026-09-06
Mon-Fri 16:35 New York LaGuardia (LGA) B 19:03 Atlanta (ATL) N
AA 4353 Non-stop Embraer EMB 175 (E75) 2:28 Effective 2026-08-05 through 2026-09-08
Sat 16:40 New York LaGuardia (LGA) B 19:05 Atlanta (ATL) N
AA 4353 Non-stop Embraer EMB 175 (E75) 2:25 Effective 2026-08-08 through 2026-09-05
Mon,Tue,Thu-Sun 16:55 New Orleans (MSY) 19:49 Chicago O'Hare (ORD) 3
AA 4353 Non-stop Embraer EMB 175 (E75) 2:54 Valid until 2026-01-05
Daily 18:55 New York LaGuardia (LGA) B 20:47 Saint Louis (STL) 1
AA 4353 Non-stop Embraer EMB 175 (E75) 2:52 Effective 2026-04-07 through 2026-05-20
Tue,Wed 18:59 New York LaGuardia (LGA) B 20:53 Chicago O'Hare (ORD) 3
AA 4353 Non-stop Embraer EMB 175 (E75) 2:54 Effective 2026-01-06 through 2026-02-11
Sat 19:10 New York LaGuardia (LGA) B 21:02 Chicago O'Hare (ORD) 3
AA 4353 Non-stop Embraer EMB 175 (E75) 2:52 Effective 2026-01-10 through 2026-02-07
Mon-Fri,Sun 19:35 Atlanta (ATL) N 21:59 New York LaGuardia (LGA) B
AA 4353 Non-stop Embraer EMB 175 (E75) 2:24 Effective 2026-08-05 through 2026-09-08
Daily 20:20 Ronald Reagan Washington (DCA) 2 22:13 Kansas City (MCI)
AA 4353 Non-stop Embraer EMB 175 (E75) 2:53 Effective 2026-09-09 through 2026-10-04
This flight number is listed as serving the following routes:


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American Airlines flight AA 4353: Multiple routes
Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4353
08:30
New York LaGuardia (LGA) B

09:41
Boston Logan (BOS) B
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:11, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
09:00
Ronald Reagan Washington (DCA) 2

10:54
Cincinnati (CVG)
Effective 2026-02-14 through 2026-03-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
Duration: 1:54, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
09:30
Philadelphia (PHL)

11:44
Indianapolis (IND)
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:14, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
09:34
Philadelphia (PHL)

11:48
Indianapolis (IND)
Effective 2026-03-14 through 2026-04-04
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:14, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
11:24
Cincinnati (CVG)

12:54
Ronald Reagan Washington (DCA) 2
Effective 2026-02-14 through 2026-03-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
Duration: 1:30, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
11:35
New York LaGuardia (LGA) B

13:46
Asheville/Hendersonville (AVL)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:11, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
13:35
Philadelphia (PHL)

15:17
Bangor (BGR)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:42, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
13:45
Chicago O'Hare (ORD) 3

16:23
New Orleans (MSY)
Valid until 2026-01-05
Mon
Tue
Wed
-
Thu
Fri
Sat
Sun
Duration: 2:38, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
14:23
Asheville/Hendersonville (AVL)

16:18
New York LaGuardia (LGA) B
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:55, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
15:59
Bangor (BGR)

17:55
Philadelphia (PHL)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
16:25
New York LaGuardia (LGA) B

18:55
Atlanta (ATL) N
Effective 2026-08-09 through 2026-09-06
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 2:30, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
16:35
New York LaGuardia (LGA) B

19:03
Atlanta (ATL) N
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 2:28, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
16:40
New York LaGuardia (LGA) B

19:05
Atlanta (ATL) N
Effective 2026-08-08 through 2026-09-05
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:25, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
16:55
New Orleans (MSY)

19:49
Chicago O'Hare (ORD) 3
Valid until 2026-01-05
Mon
Tue
Wed
-
Thu
Fri
Sat
Sun
Duration: 2:54, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
18:55
New York LaGuardia (LGA) B

20:47
Saint Louis (STL) 1
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:52, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
18:59
New York LaGuardia (LGA) B

20:53
Chicago O'Hare (ORD) 3
Effective 2026-01-06 through 2026-02-11
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:54, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
19:10
New York LaGuardia (LGA) B

21:02
Chicago O'Hare (ORD) 3
Effective 2026-01-10 through 2026-02-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:52, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
19:35
Atlanta (ATL) N

21:59
New York LaGuardia (LGA) B
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:24, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4353
20:20
Ronald Reagan Washington (DCA) 2

22:13
Kansas City (MCI)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:53, non-stop
Embraer EMB 175 (E75)
This flight number is listed as serving the following routes:
  • Asheville/Hendersonville (AVL) - New York LaGuardia (LGA)
  • Atlanta (ATL) - New York LaGuardia (LGA)
  • New Orleans (MSY) - Chicago O'Hare (ORD)
  • New York LaGuardia (LGA) - Boston Logan (BOS)
  • New York LaGuardia (LGA) - Chicago O'Hare (ORD)
  • New York LaGuardia (LGA) - Saint Louis (STL)
  • Philadelphia (PHL) - Bangor (BGR)
  • Philadelphia (PHL) - Indianapolis (IND)
  • Ronald Reagan Washington (DCA) - Cincinnati (CVG)
  • Ronald Reagan Washington (DCA) - Kansas City (MCI)
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