Alaska Airlines flight AS 4221: Multiple routes

Select flight date:
FLIGHT SCHEDULE
Direct Codeshare Flights:
Tue 15:02 Chicago O'Hare (ORD) 3 17:19 Traverse City (TVC)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:17 Operates only on 2026-01-06
Codeshare flight, operated by American Airlines.(AA 5167)
Sun 15:02 Chicago O'Hare (ORD) 3 17:19 Traverse City (TVC)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:17 Operates only on 2026-01-18
Codeshare flight, operated by American Airlines.(AA 5167)
Daily 16:45 Harrisburg (MDT) 18:00 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:15 Effective from 2026-10-05
Codeshare flight, operated by American Airlines.(AA 4004)
Daily 16:59 Ronald Reagan Washington (DCA) 2 18:48 Louisville (SDF)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:49 Effective 2026-07-02 through 2026-08-04
Codeshare flight, operated by American Airlines.(AA 5380)
Daily 17:10 Ronald Reagan Washington (DCA) 2 18:58 Louisville (SDF)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:48 Effective 2026-08-05 through 2026-09-08
Codeshare flight, operated by American Airlines.(AA 5135)
Daily 17:10 Ronald Reagan Washington (DCA) 2 19:02 Louisville (SDF)
AS 4221 Non-stop Embraer EMB 175 (E75) 1:52 Effective 2026-09-09 through 2026-10-04
Codeshare flight, operated by American Airlines.(AA 4006)
Daily 17:13 Ronald Reagan Washington (DCA) 2 19:01 Louisville (SDF)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:48 Effective 2026-05-21 through 2026-07-01
Codeshare flight, operated by American Airlines.(AA 5393)
Tue,Wed,Fri,Sat 18:24 Austin (AUS) 19:39 Dallas Fort Worth (DFW)
AS 4221 Non-stop Airbus A319 (319) 1:15 Effective 2026-02-14 through 2026-02-21
Codeshare flight, operated by American Airlines.(AA 1661)
Mon-Wed,Sat 18:24 Austin (AUS) 19:39 Dallas Fort Worth (DFW)
AS 4221 Non-stop Airbus A319 (319) 1:15 Effective 2026-02-23 through 2026-03-07
Codeshare flight, operated by American Airlines.(AA 1661)
Mon 18:30 Austin (AUS) 19:45 Dallas Fort Worth (DFW)
AS 4221 Non-stop Airbus A319 (319) 1:15 Operates only on 2026-02-16
Codeshare flight, operated by American Airlines.(AA 1661)
Daily 19:15 Ronald Reagan Washington (DCA) 2 21:01 Cincinnati (CVG)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:46 Valid until 2026-01-05
Codeshare flight, operated by American Airlines.(AA 5673)
Mon-Fri,Sun 19:30 Ronald Reagan Washington (DCA) 2 21:22 Cincinnati (CVG)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:52 Effective 2026-03-08 through 2026-04-06
Codeshare flight, operated by American Airlines.(AA 5673)
Daily 19:45 Ronald Reagan Washington (DCA) 2 21:24 Cincinnati (CVG)
AS 4221 Non-stop Canadair CRJ 700 (CR7) 1:39 Effective 2026-04-07 through 2026-05-20
Codeshare flight, operated by American Airlines.(AA 5673)
This flight number is listed as serving the following routes:


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Alaska Airlines flight AS 4221: Multiple routes
Select flight date:
FLIGHT SCHEDULE
Direct Codeshare Flights:
Alaska Airlines AS4221
15:02
Chicago O'Hare (ORD) 3

17:19
Traverse City (TVC)
Operates only on 2026-01-06
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 5167)
Duration: 1:17, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS4221
15:02
Chicago O'Hare (ORD) 3

17:19
Traverse City (TVC)
Operates only on 2026-01-18
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 5167)
Duration: 1:17, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS4221
16:45
Harrisburg (MDT)

18:00
Chicago O'Hare (ORD) 3
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 4004)
Duration: 2:15, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Codeshare Flights:
Alaska Airlines AS4221
16:59
Ronald Reagan Washington (DCA) 2

18:48
Louisville (SDF)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5380)
Duration: 1:49, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS4221
17:10
Ronald Reagan Washington (DCA) 2

18:58
Louisville (SDF)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5135)
Duration: 1:48, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS4221
17:10
Ronald Reagan Washington (DCA) 2

19:02
Louisville (SDF)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 4006)
Duration: 1:52, non-stop
Embraer EMB 175 (E75)
Direct Codeshare Flights:
Alaska Airlines AS4221
17:13
Ronald Reagan Washington (DCA) 2

19:01
Louisville (SDF)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5393)
Duration: 1:48, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS4221
18:24
Austin (AUS)

19:39
Dallas Fort Worth (DFW)
Effective 2026-02-14 through 2026-02-21
Mon
-
Tue
Wed
Thu
-
Fri
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 1661)
Duration: 1:15, non-stop
Airbus A319 (319)
Direct Codeshare Flights:
Alaska Airlines AS4221
18:24
Austin (AUS)

19:39
Dallas Fort Worth (DFW)
Effective 2026-02-23 through 2026-03-07
Mon
Tue
Wed
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 1661)
Duration: 1:15, non-stop
Airbus A319 (319)
Direct Codeshare Flights:
Alaska Airlines AS4221
18:30
Austin (AUS)

19:45
Dallas Fort Worth (DFW)
Operates only on 2026-02-16
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 1661)
Duration: 1:15, non-stop
Airbus A319 (319)
Direct Codeshare Flights:
Alaska Airlines AS4221
19:15
Ronald Reagan Washington (DCA) 2

21:01
Cincinnati (CVG)
Valid until 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5673)
Duration: 1:46, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS4221
19:30
Ronald Reagan Washington (DCA) 2

21:22
Cincinnati (CVG)
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 5673)
Duration: 1:52, non-stop
Canadair CRJ 700 (CR7)
Direct Codeshare Flights:
Alaska Airlines AS4221
19:45
Ronald Reagan Washington (DCA) 2

21:24
Cincinnati (CVG)
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 5673)
Duration: 1:39, non-stop
Canadair CRJ 700 (CR7)
This flight number is listed as serving the following routes:
  • Austin (AUS) - Dallas Fort Worth (DFW)
  • Chicago O'Hare (ORD) - Traverse City (TVC)
  • Harrisburg (MDT) - Chicago O'Hare (ORD)
  • Ronald Reagan Washington (DCA) - Cincinnati (CVG)
  • Ronald Reagan Washington (DCA) - Louisville (SDF)
All Alaska Airlines flights
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