American Airlines flight AA 5281: Cincinnati - Greenville/Spartanburg via Charlotte

Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 08:38 Cincinnati (CVG) 10:19 Charlotte (CLT)
AA 5281 Non-stop Canadair CRJ 900 (CR9) 1:41 Effective 2025-05-05 through 2025-06-04
Daily 08:40 Cincinnati (CVG) 10:24 Charlotte (CLT)
AA 5281 Non-stop Canadair CRJ 900 (CR9) 1:44 Effective 2025-06-05 through 2025-07-04
Daily 08:42 Cincinnati (CVG) 10:25 Charlotte (CLT)
AA 5281 Non-stop Canadair CRJ 900 (CR9) 1:43 Effective 2025-07-05 through 2025-08-05
Daily 08:43 Cincinnati (CVG) 10:25 Charlotte (CLT)
AA 5281 Non-stop Canadair CRJ 900 (CR9) 1:42 Effective 2025-09-03 through 2025-10-05
Daily 08:44 Cincinnati (CVG) 10:24 Charlotte (CLT)
AA 5281 Non-stop Canadair CRJ 900 (CR9) 1:40 Valid until 2025-05-04
Daily 08:47 Cincinnati (CVG) 10:25 Charlotte (CLT)
AA 5281 Non-stop Canadair CRJ 900 (CR9) 1:38 Effective 2025-08-06 through 2025-09-02
Daily 22:30 Charlotte (CLT) 23:26 Greenville/Spartanburg (GSP)
AA 5281 Non-stop Canadair CRJ 900 (CR9) 0:56 Effective 2025-10-06 through 2025-11-01
Daily 22:30 Charlotte (CLT) 23:34 Greenville/Spartanburg (GSP)
AA 5281 Non-stop Canadair CRJ 900 (CR9) 1:04 Effective 2025-11-02 through 2025-12-02
Daily 22:30 Charlotte (CLT) 23:28 Greenville/Spartanburg (GSP)
AA 5281 Non-stop Canadair CRJ 900 (CR9) 0:58 Effective 2025-12-03 through 2025-12-17
Daily 22:30 Charlotte (CLT) 23:31 Greenville/Spartanburg (GSP)
AA 5281 Non-stop Canadair CRJ 700 (CR7) 1:01 Effective 2025-12-18 through 2026-01-05


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American Airlines flight AA 5281:
Cincinnati - Greenville/Spartanburg via Charlotte
Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA5281
08:38
Cincinnati (CVG)

10:19
Charlotte (CLT)
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:41, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5281
08:40
Cincinnati (CVG)

10:24
Charlotte (CLT)
Effective 2025-06-05 through 2025-07-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:44, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5281
08:42
Cincinnati (CVG)

10:25
Charlotte (CLT)
Effective 2025-07-05 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:43, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5281
08:43
Cincinnati (CVG)

10:25
Charlotte (CLT)
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:42, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5281
08:44
Cincinnati (CVG)

10:24
Charlotte (CLT)
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:40, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5281
08:47
Cincinnati (CVG)

10:25
Charlotte (CLT)
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:38, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5281
22:30
Charlotte (CLT)

23:26
Greenville/Spartanburg (GSP)
Effective 2025-10-06 through 2025-11-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 0:56, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5281
22:30
Charlotte (CLT)

23:34
Greenville/Spartanburg (GSP)
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:04, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5281
22:30
Charlotte (CLT)

23:28
Greenville/Spartanburg (GSP)
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 0:58, non-stop
Canadair CRJ 900 (CR9)
American Airlines AA5281
22:30
Charlotte (CLT)

23:31
Greenville/Spartanburg (GSP)
Effective 2025-12-18 through 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:01, non-stop
Canadair CRJ 700 (CR7)
  • AA 5281 is a domestic flight departing from the Cincinnati airport (CVG) and arriving at Greenville/Spartanburg airport (GSP).
  • The flight runs via Charlotte (CLT).
  • The flight distance is 317 miles, or 509 km.
  • The timezone of both the departure and the arrival airports is UTC-5 . Current time at both airports is (loading...).
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