American Airlines flight AA 4540: Multiple routes

Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Sat 06:00 Knoxville (TYS) 07:31 Ronald Reagan Washington (DCA) 2
AA 4540 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:31 Effective 2025-05-10 through 2025-05-31
Daily 06:02 John Glenn Columbus (CMH) 07:40 Philadelphia (PHL)
AA 4540 Non-stop Embraer EMB 175 (E75) 1:38 Effective 2025-12-03 through 2025-12-17
Daily 06:02 John Glenn Columbus (CMH) 07:40 Philadelphia (PHL)
AA 4540 Non-stop Embraer EMB 175 (E75) 1:38 Effective 2026-01-06 through 2026-02-11
Daily 06:03 John Glenn Columbus (CMH) 07:40 Philadelphia (PHL)
AA 4540 Non-stop Embraer EMB 175 (E75) 1:37 Effective 2025-11-02 through 2025-12-02
Daily 06:12 John Glenn Columbus (CMH) 07:40 Philadelphia (PHL)
AA 4540 Non-stop Embraer EMB 175 (E75) 1:28 Effective from 2026-02-12
Daily 07:30 Ronald Reagan Washington (DCA) 2 10:29 Key West (EYW)
AA 4540 Non-stop Embraer EMB 175 (E75) 2:59 Valid until 2025-05-04
Daily 08:15 Ronald Reagan Washington (DCA) 2 11:30 Key West (EYW)
AA 4540 Non-stop Embraer EMB 175 (E75) 3:15 Effective 2025-10-06 through 2025-10-25
Mon-Fri,Sun 08:20 Ronald Reagan Washington (DCA) 2 11:22 Key West (EYW)
AA 4540 Non-stop Embraer EMB 175 (E75) 3:02 Effective 2025-07-06 through 2025-08-05
Daily 08:20 Ronald Reagan Washington (DCA) 2 11:23 Key West (EYW)
AA 4540 Non-stop Embraer EMB 175 (E75) 3:03 Effective 2025-08-06 through 2025-09-02
Daily 08:20 Ronald Reagan Washington (DCA) 2 11:32 Key West (EYW)
AA 4540 Non-stop Embraer EMB 175 (E75) 3:12 Effective 2025-09-03 through 2025-10-05
Daily 08:25 Ronald Reagan Washington (DCA) 2 11:23 Key West (EYW)
AA 4540 Non-stop Embraer EMB 175 (E75) 2:58 Effective 2025-06-05 through 2025-07-04
This flight number is listed as serving the following routes:


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American Airlines flight AA 4540: Multiple routes
Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4540
06:00
Knoxville (TYS)

07:31
Ronald Reagan Washington (DCA) 2
Effective 2025-05-10 through 2025-05-31
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:31, non-stop
Embraer EMB 170 / EMB 175 (E70)
American Airlines AA4540
06:02
John Glenn Columbus (CMH)

07:40
Philadelphia (PHL)
Effective 2025-12-03 through 2025-12-17
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:38, non-stop
Embraer EMB 175 (E75)
American Airlines AA4540
06:02
John Glenn Columbus (CMH)

07:40
Philadelphia (PHL)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:38, non-stop
Embraer EMB 175 (E75)
American Airlines AA4540
06:03
John Glenn Columbus (CMH)

07:40
Philadelphia (PHL)
Effective 2025-11-02 through 2025-12-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:37, non-stop
Embraer EMB 175 (E75)
American Airlines AA4540
06:12
John Glenn Columbus (CMH)

07:40
Philadelphia (PHL)
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:28, non-stop
Embraer EMB 175 (E75)
American Airlines AA4540
07:30
Ronald Reagan Washington (DCA) 2

10:29
Key West (EYW)
Valid until 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:59, non-stop
Embraer EMB 175 (E75)
American Airlines AA4540
08:15
Ronald Reagan Washington (DCA) 2

11:30
Key West (EYW)
Effective 2025-10-06 through 2025-10-25
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:15, non-stop
Embraer EMB 175 (E75)
American Airlines AA4540
08:20
Ronald Reagan Washington (DCA) 2

11:22
Key West (EYW)
Effective 2025-07-06 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 3:02, non-stop
Embraer EMB 175 (E75)
American Airlines AA4540
08:20
Ronald Reagan Washington (DCA) 2

11:23
Key West (EYW)
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:03, non-stop
Embraer EMB 175 (E75)
American Airlines AA4540
08:20
Ronald Reagan Washington (DCA) 2

11:32
Key West (EYW)
Effective 2025-09-03 through 2025-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 3:12, non-stop
Embraer EMB 175 (E75)
American Airlines AA4540
08:25
Ronald Reagan Washington (DCA) 2

11:23
Key West (EYW)
Effective 2025-06-05 through 2025-07-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:58, non-stop
Embraer EMB 175 (E75)
This flight number is listed as serving the following routes:
  • John Glenn Columbus (CMH) - Philadelphia (PHL)
  • Knoxville (TYS) - Ronald Reagan Washington (DCA)
  • Ronald Reagan Washington (DCA) - Key West (EYW)
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