American Airlines flight AA 4381: Multiple routes

Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 06:29 New York LaGuardia (LGA) B 08:12 Saint Louis (STL) 1
AA 4381 Non-stop Embraer EMB 175 (E75) 2:43 Effective 2025-05-05 through 2025-06-04
Mon,Fri,Sun 06:34 New York LaGuardia (LGA) B 08:27 Saint Louis (STL) 1
AA 4381 Non-stop Embraer EMB 175 (E75) 2:53 Effective 2024-11-01 through 2024-11-04
Mon-Fri,Sun 06:42 New York LaGuardia (LGA) B 08:27 Saint Louis (STL) 1
AA 4381 Non-stop Embraer EMB 175 (E75) 2:45 Effective 2024-10-07 through 2024-10-25
Mon,Thu,Fri 06:45 New York LaGuardia (LGA) B 08:26 Saint Louis (STL) 1
AA 4381 Non-stop Embraer EMB 175 (E75) 2:41 Effective 2024-09-05 through 2024-10-04
Mon-Fri,Sun 06:49 New York LaGuardia (LGA) B 08:27 Saint Louis (STL) 1
AA 4381 Non-stop Embraer EMB 175 (E75) 2:38 Valid until 2024-09-03
Daily 06:55 New York LaGuardia (LGA) B 08:36 Saint Louis (STL) 1
AA 4381 Non-stop Embraer EMB 175 (E75) 2:41 Effective from 2025-06-05
Tue,Wed 06:59 New York LaGuardia (LGA) B 08:41 Saint Louis (STL) 1
AA 4381 Non-stop Embraer EMB 175 (E75) 2:42 Effective 2024-09-04 through 2024-10-02
Sun 07:00 New York LaGuardia (LGA) B 08:46 Saint Louis (STL) 1
AA 4381 Non-stop Embraer EMB 175 (E75) 2:46 Effective 2024-09-08 through 2024-10-06
Mon,Sun 07:00 New York LaGuardia (LGA) B 08:53 Saint Louis (STL) 1
AA 4381 Non-stop Embraer EMB 175 (E75) 2:53 Effective 2024-10-27 through 2024-10-28
Tue-Thu 07:00 New York LaGuardia (LGA) B 08:57 Saint Louis (STL) 1
AA 4381 Non-stop Embraer EMB 175 (E75) 2:57 Effective 2024-10-29 through 2024-10-31
Daily 07:40 New York LaGuardia (LGA) B 09:36 Saint Louis (STL) 1
AA 4381 Non-stop Embraer EMB 175 (E75) 2:56 Effective 2024-12-19 through 2025-01-06
Daily 09:02 Saint Louis (STL) 1 12:30 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 2:28 Effective 2025-05-05 through 2025-06-04
Daily 10:19 Saint Louis (STL) 1 13:39 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 2:20 Effective 2024-12-19 through 2025-01-06
Thu,Fri 10:45 John Glenn Columbus (CMH) 12:30 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:45 Effective 2024-11-28 through 2024-11-29
Sun 10:50 John Glenn Columbus (CMH) 12:30 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:40 Effective 2024-11-10 through 2024-11-17
Daily 10:52 John Glenn Columbus (CMH) 12:38 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:46 Effective 2024-12-05 through 2024-12-18
Daily 11:03 Saint Louis (STL) 1 14:29 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 2:26 Effective from 2025-06-05
Daily 11:48 John Glenn Columbus (CMH) 13:34 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:46 Effective 2025-04-04 through 2025-05-04
Daily 11:54 John Glenn Columbus (CMH) 13:39 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:45 Effective 2025-01-07 through 2025-02-12
Daily 11:55 John Glenn Columbus (CMH) 13:39 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:44 Effective 2025-03-06 through 2025-04-03
Daily 11:56 John Glenn Columbus (CMH) 13:41 New York LaGuardia (LGA) B
AA 4381 Non-stop Embraer EMB 175 (E75) 1:45 Effective 2025-02-13 through 2025-03-05
This flight number is listed as serving the following routes:


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American Airlines flight AA 4381: Multiple routes
Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4381
06:29
New York LaGuardia (LGA) B

08:12
Saint Louis (STL) 1
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:43, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
06:34
New York LaGuardia (LGA) B

08:27
Saint Louis (STL) 1
Effective 2024-11-01 through 2024-11-04
Mon
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
Duration: 2:53, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
06:42
New York LaGuardia (LGA) B

08:27
Saint Louis (STL) 1
Effective 2024-10-07 through 2024-10-25
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:45, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
06:45
New York LaGuardia (LGA) B

08:26
Saint Louis (STL) 1
Effective 2024-09-05 through 2024-10-04
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
-
Duration: 2:41, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
06:49
New York LaGuardia (LGA) B

08:27
Saint Louis (STL) 1
Valid until 2024-09-03
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:38, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
06:55
New York LaGuardia (LGA) B

08:36
Saint Louis (STL) 1
Effective from 2025-06-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:41, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
06:59
New York LaGuardia (LGA) B

08:41
Saint Louis (STL) 1
Effective 2024-09-04 through 2024-10-02
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:42, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
07:00
New York LaGuardia (LGA) B

08:46
Saint Louis (STL) 1
Effective 2024-09-08 through 2024-10-06
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 2:46, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
07:00
New York LaGuardia (LGA) B

08:53
Saint Louis (STL) 1
Effective 2024-10-27 through 2024-10-28
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 2:53, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
07:00
New York LaGuardia (LGA) B

08:57
Saint Louis (STL) 1
Effective 2024-10-29 through 2024-10-31
Mon
-
Tue
Wed
Thu
Fri
-
Sat
-
Sun
-
Duration: 2:57, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
07:40
New York LaGuardia (LGA) B

09:36
Saint Louis (STL) 1
Effective 2024-12-19 through 2025-01-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:56, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
09:02
Saint Louis (STL) 1

12:30
New York LaGuardia (LGA) B
Effective 2025-05-05 through 2025-06-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:28, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
10:19
Saint Louis (STL) 1

13:39
New York LaGuardia (LGA) B
Effective 2024-12-19 through 2025-01-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:20, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
10:45
John Glenn Columbus (CMH)

12:30
New York LaGuardia (LGA) B
Effective 2024-11-28 through 2024-11-29
Mon
-
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
-
Duration: 1:45, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
10:50
John Glenn Columbus (CMH)

12:30
New York LaGuardia (LGA) B
Effective 2024-11-10 through 2024-11-17
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:40, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
10:52
John Glenn Columbus (CMH)

12:38
New York LaGuardia (LGA) B
Effective 2024-12-05 through 2024-12-18
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:46, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
11:03
Saint Louis (STL) 1

14:29
New York LaGuardia (LGA) B
Effective from 2025-06-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:26, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
11:48
John Glenn Columbus (CMH)

13:34
New York LaGuardia (LGA) B
Effective 2025-04-04 through 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:46, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
11:54
John Glenn Columbus (CMH)

13:39
New York LaGuardia (LGA) B
Effective 2025-01-07 through 2025-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:45, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
11:55
John Glenn Columbus (CMH)

13:39
New York LaGuardia (LGA) B
Effective 2025-03-06 through 2025-04-03
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:44, non-stop
Embraer EMB 175 (E75)
American Airlines AA4381
11:56
John Glenn Columbus (CMH)

13:41
New York LaGuardia (LGA) B
Effective 2025-02-13 through 2025-03-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:45, non-stop
Embraer EMB 175 (E75)
This flight number is listed as serving the following routes:
  • John Glenn Columbus (CMH) - New York LaGuardia (LGA)
  • New York LaGuardia (LGA) - Saint Louis (STL)
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