Alaska Airlines flight AS 4221: Multiple routes

Select flight date:
FLIGHT SCHEDULE
Direct Codeshare Flights:
Daily 09:50 Chicago O'Hare (ORD) 3 10:51 Madison (MSN)
AS 4221 Non-stop Canadair CRJ (CRJ) 1:01 Effective 2025-04-04 through 2025-05-04
Codeshare flight, operated by American Airlines.(AA 6100)
Daily 11:33 Chicago O'Hare (ORD) 3 14:50 New York John F. Kennedy (JFK) 8
AS 4221 Non-stop Boeing 737-800 (738) 2:17 Valid until 2024-09-03
Codeshare flight, operated by American Airlines.(AA 332)
Daily 11:42 Madison (MSN) 12:45 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Canadair CRJ (CRJ) 1:03 Effective 2025-04-04 through 2025-05-04
Codeshare flight, operated by American Airlines.(AA 6100)
Mon,Thu,Fri,Sun 13:14 Chicago O'Hare (ORD) 3 14:12 Madison (MSN)
AS 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 0:58 Effective 2024-11-08 through 2024-11-14
Codeshare flight, operated by American Airlines.(AA 4013)
Mon,Thu-Sun 13:14 Chicago O'Hare (ORD) 3 14:12 Madison (MSN)
AS 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 0:58 Effective 2024-11-17 through 2024-11-25
Codeshare flight, operated by American Airlines.(AA 4013)
Mon-Wed,Sat,Sun 13:14 Chicago O'Hare (ORD) 3 14:12 Madison (MSN)
AS 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 0:58 Effective 2024-11-26 through 2024-12-04
Codeshare flight, operated by American Airlines.(AA 4013)
Sat 13:40 Chicago O'Hare (ORD) 3 16:45 New York John F. Kennedy (JFK) 8
AS 4221 Non-stop Boeing 787 (787) 2:05 Operates only on 2024-10-26
Codeshare flight, operated by American Airlines.(AA 2552)
Mon,Thu,Fri,Sun 14:42 Madison (MSN) 15:42 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:00 Effective 2024-11-08 through 2024-11-14
Codeshare flight, operated by American Airlines.(AA 4013)
Mon,Thu-Sun 14:42 Madison (MSN) 15:42 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:00 Effective 2024-11-17 through 2024-11-25
Codeshare flight, operated by American Airlines.(AA 4013)
Mon-Wed,Sat,Sun 14:42 Madison (MSN) 15:42 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:00 Effective 2024-11-26 through 2024-12-04
Codeshare flight, operated by American Airlines.(AA 4013)
Tue,Wed 16:30 Chicago O'Hare (ORD) 3 17:27 Madison (MSN)
AS 4221 Non-stop Embraer EMB 175 (E75) 0:57 Effective 2024-11-05 through 2024-11-06
Codeshare flight, operated by American Airlines.(AA 4645)
Daily 16:45 Chicago O'Hare (ORD) 3 19:00 Cincinnati (CVG)
AS 4221 Non-stop Canadair CRJ (CRJ) 1:15 Effective 2024-12-05 through 2024-12-18
Codeshare flight, operated by American Airlines.(AA 6100)
Daily 16:45 Chicago O'Hare (ORD) 3 17:41 Madison (MSN)
AS 4221 Non-stop Embraer EMB 175 (E75) 0:56 Effective 2025-01-07 through 2025-02-12
Codeshare flight, operated by American Airlines.(AA 3956)
Mon,Thu,Fri,Sun 16:50 Austin (AUS) 19:30 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Boeing 737-800 (738) 2:40 Effective 2024-10-07 through 2024-10-28
Codeshare flight, operated by American Airlines.(AA 1398)
Fri,Sun 16:50 Austin (AUS) 19:30 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Boeing 737-800 (738) 2:40 Effective 2024-11-01 through 2024-11-03
Codeshare flight, operated by American Airlines.(AA 1398)
Thu,Fri 16:50 Chicago O'Hare (ORD) 3 17:48 Madison (MSN)
AS 4221 Non-stop Embraer ERJ 145 (ER4) 0:58 Effective 2024-11-28 through 2024-11-29
Codeshare flight, operated by American Airlines.(AA 5807)
Thu,Sun 17:46 Dallas Fort Worth (DFW) 19:18 McAllen/Mission (MFE)
AS 4221 Non-stop Embraer EMB 175 (E75) 1:32 Effective 2024-09-08 through 2024-10-06
Codeshare flight, operated by American Airlines.(AA 3392)
Tue,Wed,Sat 17:55 Chicago O'Hare (ORD) 3 18:54 Madison (MSN)
AS 4221 Non-stop Embraer ERJ 145 (ER4) 0:59 Effective 2024-09-04 through 2024-10-05
Codeshare flight, operated by American Airlines.(AA 5855)
Tue,Wed 18:07 Madison (MSN) 19:11 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Embraer EMB 175 (E75) 1:04 Effective 2024-11-05 through 2024-11-06
Codeshare flight, operated by American Airlines.(AA 4645)
Daily 18:43 Madison (MSN) 19:45 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Embraer EMB 175 (E75) 1:02 Effective 2025-01-07 through 2025-02-12
Codeshare flight, operated by American Airlines.(AA 3956)
Daily 19:14 Cincinnati (CVG) 19:41 Chicago O'Hare (ORD) 3
AS 4221 Non-stop Canadair CRJ (CRJ) 1:27 Effective 2024-12-05 through 2024-12-18
Codeshare flight, operated by American Airlines.(AA 6100)
Thu,Sun 19:52 McAllen/Mission (MFE) 21:34 Dallas Fort Worth (DFW)
AS 4221 Non-stop Embraer EMB 175 (E75) 1:42 Effective 2024-09-08 through 2024-10-06
Codeshare flight, operated by American Airlines.(AA 3392)
Daily 20:15 Chicago O'Hare (ORD) 3 21:10 Madison (MSN)
AS 4221 Non-stop Embraer EMB 175 (E75) 0:55 Effective 2025-02-13 through 2025-03-05
Codeshare flight, operated by American Airlines.(AA 3886)
Daily 20:15 Chicago O'Hare (ORD) 3 21:11 Madison (MSN)
AS 4221 Non-stop Embraer EMB 175 (E75) 0:56 Effective 2025-03-06 through 2025-04-03
Codeshare flight, operated by American Airlines.(AA 3886)
Fri 20:45 Chicago O'Hare (ORD) 3 21:48 Madison (MSN)
AS 4221 Non-stop Embraer EMB 175 (E75) 1:03 Operates only on 2024-11-15
Codeshare flight, operated by American Airlines.(AA 4054)
This flight number is listed as serving the following routes:


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Alaska Airlines flight AS 4221: Multiple routes
Select flight date:
FLIGHT SCHEDULE
Direct Codeshare Flights:
Alaska Airlines AS4221
09:50
Chicago O'Hare (ORD) 3

10:51
Madison (MSN)
Effective 2025-04-04 through 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 6100)
Duration: 1:01, non-stop
Canadair CRJ (CRJ)
Alaska Airlines AS4221
11:33
Chicago O'Hare (ORD) 3

14:50
New York John F. Kennedy (JFK) 8
Valid until 2024-09-03
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 332)
Duration: 2:17, non-stop
Boeing 737-800 (738)
Alaska Airlines AS4221
11:42
Madison (MSN)

12:45
Chicago O'Hare (ORD) 3
Effective 2025-04-04 through 2025-05-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 6100)
Duration: 1:03, non-stop
Canadair CRJ (CRJ)
Alaska Airlines AS4221
13:14
Chicago O'Hare (ORD) 3

14:12
Madison (MSN)
Effective 2024-11-08 through 2024-11-14
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 4013)
Duration: 0:58, non-stop
Embraer EMB 170 / EMB 175 (E70)
Alaska Airlines AS4221
13:14
Chicago O'Hare (ORD) 3

14:12
Madison (MSN)
Effective 2024-11-17 through 2024-11-25
Mon
Tue
-
Wed
-
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 4013)
Duration: 0:58, non-stop
Embraer EMB 170 / EMB 175 (E70)
Alaska Airlines AS4221
13:14
Chicago O'Hare (ORD) 3

14:12
Madison (MSN)
Effective 2024-11-26 through 2024-12-04
Mon
Tue
Wed
Thu
-
Fri
-
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 4013)
Duration: 0:58, non-stop
Embraer EMB 170 / EMB 175 (E70)
Alaska Airlines AS4221
13:40
Chicago O'Hare (ORD) 3

16:45
New York John F. Kennedy (JFK) 8
Operates only on 2024-10-26
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 2552)
Duration: 2:05, non-stop
Boeing 787 (787)
Alaska Airlines AS4221
14:42
Madison (MSN)

15:42
Chicago O'Hare (ORD) 3
Effective 2024-11-08 through 2024-11-14
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 4013)
Duration: 1:00, non-stop
Embraer EMB 170 / EMB 175 (E70)
Alaska Airlines AS4221
14:42
Madison (MSN)

15:42
Chicago O'Hare (ORD) 3
Effective 2024-11-17 through 2024-11-25
Mon
Tue
-
Wed
-
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 4013)
Duration: 1:00, non-stop
Embraer EMB 170 / EMB 175 (E70)
Alaska Airlines AS4221
14:42
Madison (MSN)

15:42
Chicago O'Hare (ORD) 3
Effective 2024-11-26 through 2024-12-04
Mon
Tue
Wed
Thu
-
Fri
-
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 4013)
Duration: 1:00, non-stop
Embraer EMB 170 / EMB 175 (E70)
Alaska Airlines AS4221
16:30
Chicago O'Hare (ORD) 3

17:27
Madison (MSN)
Effective 2024-11-05 through 2024-11-06
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 4645)
Duration: 0:57, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4221
16:45
Chicago O'Hare (ORD) 3

19:00
Cincinnati (CVG)
Effective 2024-12-05 through 2024-12-18
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 6100)
Duration: 1:15, non-stop
Canadair CRJ (CRJ)
Alaska Airlines AS4221
16:45
Chicago O'Hare (ORD) 3

17:41
Madison (MSN)
Effective 2025-01-07 through 2025-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 3956)
Duration: 0:56, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4221
16:50
Austin (AUS)

19:30
Chicago O'Hare (ORD) 3
Effective 2024-10-07 through 2024-10-28
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 1398)
Duration: 2:40, non-stop
Boeing 737-800 (738)
Alaska Airlines AS4221
16:50
Austin (AUS)

19:30
Chicago O'Hare (ORD) 3
Effective 2024-11-01 through 2024-11-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 1398)
Duration: 2:40, non-stop
Boeing 737-800 (738)
Alaska Airlines AS4221
16:50
Chicago O'Hare (ORD) 3

17:48
Madison (MSN)
Effective 2024-11-28 through 2024-11-29
Mon
-
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 5807)
Duration: 0:58, non-stop
Embraer ERJ 145 (ER4)
Alaska Airlines AS4221
17:46
Dallas Fort Worth (DFW)

19:18
McAllen/Mission (MFE)
Effective 2024-09-08 through 2024-10-06
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 3392)
Duration: 1:32, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4221
17:55
Chicago O'Hare (ORD) 3

18:54
Madison (MSN)
Effective 2024-09-04 through 2024-10-05
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
Sun
-
Codeshare flight, operated by American Airlines. (AA 5855)
Duration: 0:59, non-stop
Embraer ERJ 145 (ER4)
Alaska Airlines AS4221
18:07
Madison (MSN)

19:11
Chicago O'Hare (ORD) 3
Effective 2024-11-05 through 2024-11-06
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 4645)
Duration: 1:04, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4221
18:43
Madison (MSN)

19:45
Chicago O'Hare (ORD) 3
Effective 2025-01-07 through 2025-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 3956)
Duration: 1:02, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4221
19:14
Cincinnati (CVG)

19:41
Chicago O'Hare (ORD) 3
Effective 2024-12-05 through 2024-12-18
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 6100)
Duration: 1:27, non-stop
Canadair CRJ (CRJ)
Alaska Airlines AS4221
19:52
McAllen/Mission (MFE)

21:34
Dallas Fort Worth (DFW)
Effective 2024-09-08 through 2024-10-06
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
Codeshare flight, operated by American Airlines. (AA 3392)
Duration: 1:42, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4221
20:15
Chicago O'Hare (ORD) 3

21:10
Madison (MSN)
Effective 2025-02-13 through 2025-03-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 3886)
Duration: 0:55, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4221
20:15
Chicago O'Hare (ORD) 3

21:11
Madison (MSN)
Effective 2025-03-06 through 2025-04-03
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Codeshare flight, operated by American Airlines. (AA 3886)
Duration: 0:56, non-stop
Embraer EMB 175 (E75)
Alaska Airlines AS4221
20:45
Chicago O'Hare (ORD) 3

21:48
Madison (MSN)
Operates only on 2024-11-15
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Codeshare flight, operated by American Airlines. (AA 4054)
Duration: 1:03, non-stop
Embraer EMB 175 (E75)
This flight number is listed as serving the following routes:
  • Austin (AUS) - Chicago O'Hare (ORD)
  • Chicago O'Hare (ORD) - New York John F. Kennedy (JFK)
  • Cincinnati (CVG) - Chicago O'Hare (ORD)
  • Madison (MSN) - Chicago O'Hare (ORD)
  • McAllen/Mission (MFE) - Dallas Fort Worth (DFW)
All Alaska Airlines flights
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